Caracterização físico-química do fármaco antichagásico benznidazol Physicochemical characterization of antichagasic benznidazole

Currently, benznidazole (BNZ) is a unique therapeutic alternative available in Brazil to treat Chagas disease. Despite its traditional medical use, little is known about the chemical nature of this drug. A detailed study of the physicochemical properties of BNZ was performed using multiple assays. T...

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Bibliographic Details
Published in:Química nova 2010-01, Vol.33 (8), p.1714-1719
Main Authors: Flávia Pires Maximiano, Guilherme Hideki Yoshizane Costa, Jacqueline de Souza, Marcílio Sérgio Soares da Cunha-Filho
Format: Article
Language:English
Subjects:
benznidazole
biopharmaceutical classification
preformulation
Online Access:Get full text
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Summary:Currently, benznidazole (BNZ) is a unique therapeutic alternative available in Brazil to treat Chagas disease. Despite its traditional medical use, little is known about the chemical nature of this drug. A detailed study of the physicochemical properties of BNZ was performed using multiple assays. Thermal, diffractometric, morphological and reological drug profiles were obtained. The partition coefficient and solubility results allowed this drug to be classified as a class IV drug according to the biopharmaceutical classification system. This information will be useful for the development of more effective BNZ formulations and for establishing the quality profile of BNZ.
ISSN:0100-4042
1678-7064
DOI:10.1590/S0100-40422010000800018