Caracterização físico-química do fármaco antichagásico benznidazol Physicochemical characterization of antichagasic benznidazole

Currently, benznidazole (BNZ) is a unique therapeutic alternative available in Brazil to treat Chagas disease. Despite its traditional medical use, little is known about the chemical nature of this drug. A detailed study of the physicochemical properties of BNZ was performed using multiple assays. T...

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Published in:Química nova 2010-01, Vol.33 (8), p.1714-1719
Main Authors: Flávia Pires Maximiano, Guilherme Hideki Yoshizane Costa, Jacqueline de Souza, Marcílio Sérgio Soares da Cunha-Filho
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Language:English
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benznidazole
biopharmaceutical classification
preformulation
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container_end_page 1719
container_issue 8
container_start_page 1714
container_title Química nova
container_volume 33
creator Flávia Pires Maximiano
Guilherme Hideki Yoshizane Costa
Jacqueline de Souza
Marcílio Sérgio Soares da Cunha-Filho
description Currently, benznidazole (BNZ) is a unique therapeutic alternative available in Brazil to treat Chagas disease. Despite its traditional medical use, little is known about the chemical nature of this drug. A detailed study of the physicochemical properties of BNZ was performed using multiple assays. Thermal, diffractometric, morphological and reological drug profiles were obtained. The partition coefficient and solubility results allowed this drug to be classified as a class IV drug according to the biopharmaceutical classification system. This information will be useful for the development of more effective BNZ formulations and for establishing the quality profile of BNZ.
doi_str_mv 10.1590/S0100-40422010000800018
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subjects benznidazole
biopharmaceutical classification
preformulation
title Caracterização físico-química do fármaco antichagásico benznidazol Physicochemical characterization of antichagasic benznidazole
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