Percutaneous Closure of Left Atrial Appendage affects Mid-Term Release of MR-proANP

The left atrial appendage (LAA) represents both a predisposing source of thrombus formation and of neuro-humoral haemostasis. This study aims to evaluate changes of biomarker expression before and after successful percutaneous closure of the LAA. Patients with atrial fibrillation and contraindicatio...

Full description

Saved in:
Bibliographic Details
Published in:Scientific reports 2017-08, Vol.7 (1), p.9028-9028, Article 9028
Main Authors: Behnes, Michael, Sartorius, Benjamin, Wenke, Annika, Lang, Siegfried, Hoffmann, Ursula, Fastner, Christian, Borggrefe, Martin, Roth, Thomas, Triebel, Jakob, Bertsch, Thomas, Akin, Ibrahim
Format: Article
Language:English
Subjects:
692/308/53/2422
692/4019/2776
Atrial natriuretic peptide
Blood
Blood levels
Brain natriuretic peptide
Calcium-binding protein
Cerebral blood flow
Fibrillation
Humanities and Social Sciences
Ischemia
multidisciplinary
Plasma
Science
Science (multidisciplinary)
Serum levels
Thrombosis
Troponin
Troponin I
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The left atrial appendage (LAA) represents both a predisposing source of thrombus formation and of neuro-humoral haemostasis. This study aims to evaluate changes of biomarker expression before and after successful percutaneous closure of the LAA. Patients with atrial fibrillation and contraindication for oral anticoagulant therapy were enrolled. Blood samples were taken within 24 hours before (T1) and at least 6 months (mid-term) (T2) after successful implantation of LAA occlusion devices. Blood levels of high sensitivity troponin I and T (hsTnI, hsTnT), aminoterminal pro-brain natriuretic peptide (NT-proBNP) and mid-regional pro-atrial natriuretic peptide (MR-proANP) were evaluated at both time points. A total of 42 patients with successful percutaneous LAA closure were included. Median mid-term follow-up was of 183 days. HsTnT, hsTnI and NT-proBNP did not show any significant differences over time. Serum levels of MR-proANP increased significantly between immediate pre-intervention (T1: median = 245.7 pmol/l, IQR 155.8–361.3 pmol/l) and at mid-term follow-up (T2: median = 254 pmol/l, IQR 183.4–396.4 pmol/l) (p = 0.037). These results indicate, that percutaneous LAA closure affects neuro-humoral haemostasis by increasing MR-proANP serum levels at mid-term follow-up.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-017-08999-4