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Emerging therapeutic targets in oral squamous cell carcinoma: Insights from genetic alterations
•EGFR overexpression in OSCC drives tumor growth and metastasis, highlighting its potential as a therapeutic target.•TP53 mutations disrupt cell cycle regulation in OSCC, fueling oncogenesis and treatment resistance.•Dysregulation of the PI3K/AKT/mTOR pathway in OSCC promotes cell survival and proli...
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Published in: | Oral oncology reports 2024-06, Vol.10, p.100548, Article 100548 |
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Main Authors: | , |
Format: | Article |
Language: | English |
Citations: | Items that this one cites |
Online Access: | Get full text |
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Summary: | •EGFR overexpression in OSCC drives tumor growth and metastasis, highlighting its potential as a therapeutic target.•TP53 mutations disrupt cell cycle regulation in OSCC, fueling oncogenesis and treatment resistance.•Dysregulation of the PI3K/AKT/mTOR pathway in OSCC promotes cell survival and proliferation.•Immunotherapy shows promise in OSCC, particularly in patients with high tumor mutational burden or PD-L1 expression.•Genetic profiling of OSCC tumors may guide personalized treatment strategies for improved patient outcomes. |
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ISSN: | 2772-9060 2772-9060 |
DOI: | 10.1016/j.oor.2024.100548 |