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Emerging therapeutic targets in oral squamous cell carcinoma: Insights from genetic alterations

•EGFR overexpression in OSCC drives tumor growth and metastasis, highlighting its potential as a therapeutic target.•TP53 mutations disrupt cell cycle regulation in OSCC, fueling oncogenesis and treatment resistance.•Dysregulation of the PI3K/AKT/mTOR pathway in OSCC promotes cell survival and proli...

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Bibliographic Details
Published in:Oral oncology reports 2024-06, Vol.10, p.100548, Article 100548
Main Authors: Patil, Santosh R., Veeraraghavan, Vishnu Priya
Format: Article
Language:English
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Summary:•EGFR overexpression in OSCC drives tumor growth and metastasis, highlighting its potential as a therapeutic target.•TP53 mutations disrupt cell cycle regulation in OSCC, fueling oncogenesis and treatment resistance.•Dysregulation of the PI3K/AKT/mTOR pathway in OSCC promotes cell survival and proliferation.•Immunotherapy shows promise in OSCC, particularly in patients with high tumor mutational burden or PD-L1 expression.•Genetic profiling of OSCC tumors may guide personalized treatment strategies for improved patient outcomes.
ISSN:2772-9060
2772-9060
DOI:10.1016/j.oor.2024.100548