Effect of Disease Severity on Comorbid Conditions in Atopic Dermatitis: Nationwide Registry-Based Investigation in Finnish Adults

The majority of registry studies on atopic dermatitis include only patients and diagnoses from specialized healthcare. The aim of this retrospective, real-world cohort study was to evaluate the effect of atopic dermatitis severity on comorbidities and total morbidity, with comprehensive data from bo...

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Bibliographic Details
Published in:Acta dermato-venereologica 2023-03, Vol.103, p.adv00882-adv00882
Main Authors: Kiiski, Ville, Ukkola-Vuoti, Liisa, Vikkula, Johanna, Ranta, Martta, Lassenius, Mariann I, Kopra, Jaakko
Format: Article
Language:English
Subjects:
Adult
atopic dermatitis
Cohort Studies
cohort study
comorbidities
Dermatitis, Atopic - diagnosis
Dermatitis, Atopic - epidemiology
epidemiology
Female
Finland - epidemiology
Humans
Male
Middle Aged
Original Report
Patient Acuity
Registries
Retrospective Studies
severity
Severity of Illness Index
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Summary:The majority of registry studies on atopic dermatitis include only patients and diagnoses from specialized healthcare. The aim of this retrospective, real-world cohort study was to evaluate the effect of atopic dermatitis severity on comorbidities and total morbidity, with comprehensive data from both primary and specialty healthcare registries covering the entire Finnish adult population. In total, 124,038 patients were identified (median age 46 years; 68% female) and stratified by disease severity. All regression analyses (median follow-up 7.0 years) were adjusted at a minimum for age, sex, obesity, and educational level. Compared with mild atopic dermatitis, severe atopic dermatitis was significantly associated with multiple morbidities, including neurotic, stress-related and somatoform disorders, abscesses, erysipelas/cellulitis, impetigo, herpes zoster, extragenital herpes, bacterial conjunctivitis, septicaemia, lymphomas, alopecia areata, urticaria, other dermatitis, contact allergy, osteoporosis, and intervertebral disc disorders (p 
ISSN:0001-5555
1651-2057
DOI:10.2340/actadv.v103.4447