Immunomodulatory effects of phytogenics in chickens and pigs - A review

Environmental stressors like pathogens and toxins may depress the animal immune system through invasion of the gastrointestinal tract (GIT) tract, where they may impair performance and production, as well as lead to increased mortality rates. Therefore, protection of the GIT tract and improving anim...

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Bibliographic Details
Published in:Animal bioscience 2018, 31(5), , pp.617-627
Main Authors: Huang, C M, Lee, T T
Format: Article
Language:English
Subjects:
Domestic Animals
Immune Response
Inflammatory Cytokines
Phytochemicals
Phytogenics
Review Paper
축산학
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Summary:Environmental stressors like pathogens and toxins may depress the animal immune system through invasion of the gastrointestinal tract (GIT) tract, where they may impair performance and production, as well as lead to increased mortality rates. Therefore, protection of the GIT tract and improving animal health are top priorities in animal production. Being natural-sourced materials, phytochemicals are potential feed additives possessing multiple functions, including: anti-inflammatory, anti-fungal, anti-viral and antioxidative properties. This paper focuses on immunity-related physiological parameters regulated by phytochemicals, such as carvacrol, cinnamaldehyde, curcumin, and thymol; many studies have proven that these phytochemicals can improve animal performance and production. On the molecular level, the impact of inflammatory gene expression on underlying mechanisms was also examined, as were the effects of environmental stimuli and phytochemicals in initiating nuclear factor kappa B and mitogen-activated protein kinases signaling pathways and improving health conditions.
ISSN:1011-2367
2765-0189
1976-5517
2765-0235
DOI:10.5713/ajas.17.0657