Association between serum uric acid levels and achievement of target blood pressure among Japanese community residents with hypertension

• Published in: The journal of clinical hypertension (Greenwich, Conn.) Conn.), 2023-03, Vol.25 (3), p.295-303
• Main Authors: Yokokawa, Hirohide, Suzuki, Mai, Aoki, Nozomi, Fukuda, Hiroshi, Sato, Yuki, Hisaoka, Teruhiko, Naito, Toshio
• Format: Article
• Language: English
• Subjects: achievement rate; Age; Alcohol; Blood pressure; Blood Pressure - physiology; Body mass index; Cardiovascular disease; Cerebrovascular disease; Cholesterol; Cross-Sectional Studies; Diabetes; East Asian People; epidemiology; Female; Health behavior; Hemoglobin; High density lipoprotein; Humans; Hypertension; Hypertension - drug therapy; Hypertension - epidemiology; Kidney diseases; Lipoproteins; Male; Metabolic disorders; Original; prevention; Questionnaires; Regression analysis; Risk Factors; Sexes; Triglycerides; Uric Acid; Womens health
• ISSN: 1524-6175; 1751-7176; 1751-7176
• DOI: 10.1111/jch.14644

The authors examined the sex‐specific association between serum uric acid (SUA) levels and achievement of target blood pressure among Japanese patients with hypertension. This cross‐sectional study was conducted between January 2012 and December 2015 and examined 17 113 eligible participants (6499 men; 10 614 women) with hypertension among 66 874 Japanese community residents who underwent voluntary health checkups. Multivariate analysis was used to estimate the association between high SUA level (≥7.0 mg/dL for men and ≥6.0 mg/dL for women) and “therapeutic failure” in achieving target blood pressure (BP) of 140/90 and 130/80 mmHg in both sexes. Multivariate analysis revealed that high SUA level was significantly associated with failure to achieve the 130/80 mmHg treatment goal among men (AOR = 1.24, 95% CI = 1.03–1.50, p = .03). Among women, high SUA level was significantly associated with failure to achieve both the 130/80 and 140/90 mmHg treatment goals (AOR = 1.33, 95% CI = 1.20–1.47, p