CKD, Brain Atrophy, and White Matter Lesion Volume: The Japan Prospective Studies Collaboration for Aging and DementiaPlain-Language summary

Rationale & Objective: Chronic kidney disease, defined by albuminuria and/or reduced estimated glomerular filtration rate (eGFR), has been reported to be associated with brain atrophy and/or higher white matter lesion volume (WMLV), but there are few large-scale population-based studies assessin...

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Bibliographic Details
Published in:Kidney medicine 2023-03, Vol.5 (3), p.100593
Main Authors: Kenji Maki, Tomoyuki Ohara, Jun Hata, Mao Shibata, Naoki Hirabayashi, Takanori Honda, Satoko Sakata, Yoshihiko Furuta, Masato Akiyama, Keisuke Yamasaki, Yasuko Tatewaki, Yasuyuki Taki, Takanari Kitazono, Tatsuya Mikami, Tetsuya Maeda, Kenjiro Ono, Masaru Mimura, Kenji Nakashima, Jun-ichi Iga, Minoru Takebayashi, Toshiharu Ninomiya, Shigeyuki Nakaji, Koichi Murashita, Songee Jung, Mina Misawa, Naoki Ishizuka, Hiroshi Akasaka, Yasuo Terayama, Hisashi Yonezawa, Junko Takahashi, Moeko Noguchi-Shinohara, Junji Komatsu, Shutaro Shibata, Sohshi Yuki-Nozaki, Shogyoku Bun, Hidehito Niimura, Ryo Shikimoto, Hisashi Kida, Yasuyo Fukada, Hisanori Kowa, Toshiya Nakano, Kenji Wada, Masafumi Kishi, Tomoki Ozaki, Ayumi Tachibana, Yuta Yoshino, Jun-ichi Iga Shu-ichi Ueno, Tomohisa Ishikawa, Seiji Yuki, Asuka Koyama, Naoto Kajitani, Mamoru Hashimoto, Manabu Ikeda, Yoshihiro Kokubo, Kazuhiro Uchida, Midori Esaki, Benjamin Thyreau, Koji Yonemoto, Hisako Yoshida, Kaori Muto, Yusuke Inoue, Izen Ri, Yukihide Momozawa, Chikashi Terao, Michiaki Kubo, Yutaka Kiyohara
Format: Article
Language:English
Subjects:
Albuminuria
brain atrophy
cognitive impairment
general population
magnetic resonance imaging
white matter lesion
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Summary:Rationale & Objective: Chronic kidney disease, defined by albuminuria and/or reduced estimated glomerular filtration rate (eGFR), has been reported to be associated with brain atrophy and/or higher white matter lesion volume (WMLV), but there are few large-scale population-based studies assessing this issue. This study aimed to examine the associations between the urinary albumin-creatinine ratio (UACR) and eGFR levels and brain atrophy and WMLV in a large-scale community-dwelling older population of Japanese. Study Design: Population-based cross-sectional study. Setting & Participants: A total of 8,630 dementia-free community-dwelling Japanese aged greater than or equal to 65 years underwent brain magnetic resonance imaging scanning and screening examination of health status in 2016-2018. Exposures: UACR and eGFR levels. Outcomes: The total brain volume (TBV)-to-intracranial volume (ICV) ratio (TBV/ICV), the regional brain volume-to-TBV ratio, and the WMLV-to-ICV ratio (WMLV/ICV). Analytical Approach: The associations of UACR and eGFR levels with the TBV/ICV, the regional brain volume-to-TBV ratio, and the WMLV/ICV were assessed by using an analysis of covariance. Results: Higher UACR levels were significantly associated with lower TBV/ICV and higher geometric mean values of the WMLV/ICV (P for trend = 0.009 and
ISSN:2590-0595
2590-0595