Impact of hormone therapy side effects on health-related quality of life, distress, and well-being of breast cancer survivors

To explore the modulatory role of Adjuvant Hormone Therapy (AHT) on health-related quality of life (QoL), subjective well-being and distress prevalence in Breast Cancer (BC) survivors, considering the survival phase. Cross-sectional study with control group. 616 BC survivors participated. Examinatio...

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Bibliographic Details
Published in:Scientific reports 2022-11, Vol.12 (1), p.18673-9, Article 18673
Main Authors: Andreu, Y., Soto-Rubio, A., Ramos-Campos, M., Escriche-Saura, A., Martínez, M., Gavilá, J.
Format: Article
Language:English
Subjects:
631/477/2811
692/4028/67/1347
692/499
692/700/565/2194
692/700/565/238
692/700/784
Antineoplastic Agents, Hormonal - therapeutic use
Breast cancer
Breast Neoplasms
Cancer Survivors
Cross-Sectional Studies
Endocrine therapy
Female
Hormones
Humanities and Social Sciences
Humans
multidisciplinary
Quality of Life
Science
Science (multidisciplinary)
Side effects
Survival
Survivors
Well being
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Summary:To explore the modulatory role of Adjuvant Hormone Therapy (AHT) on health-related quality of life (QoL), subjective well-being and distress prevalence in Breast Cancer (BC) survivors, considering the survival phase. Cross-sectional study with control group. 616 BC survivors participated. Examination of interaction effect between AHT and time since end of primary treatment showed that many of the positive changes observed through the survival phases were experienced exclusively by survivors without AHT. When AHT was not prescribed, longer time elapsed was associated with a decrease in distress prevalence and an improvement in subjective well-being and QoL. It seems there is a turning point around the fifth year after finalization of primary treatment, from which the survivors without AHT significantly improve in several areas and those with AHT do so to a lesser extent. It is expected that the improvement in QoL throughout the different survival phases will have a significant impact on the adherence and maintenance of AHT and, consequently, the likelihood of survival. Thus, AHT side-effects should be routinely assessed by health care providers to gain accurate knowledge that allows improving the QoL of BC survivors.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-22971-x