Talimogene Laherparepvec: Moving From First-In-Class to Best-In-Class

Talimogene laherparepvec (T-VEC) is a modified oncolytic herpes Simplex virus, type 1 (HSV-1) encoding granulocyte-macrophage colony stimulating factor (GM-CSF). T-VEC is adapted for selective replication in melanoma cells and GM-CSF was expressed to augment host anti-tumor immunity. T-VEC is indica...

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Bibliographic Details
Published in:Frontiers in molecular biosciences 2022-02, Vol.9, p.834841-834841
Main Authors: Kaufman, Howard L, Shalhout, Sophia Z, Iodice, Gail
Format: Article
Language:English
Subjects:
biomarker
cancer
immunotherapy
Molecular Biosciences
oncolytic virus (OV)
treatment
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Summary:Talimogene laherparepvec (T-VEC) is a modified oncolytic herpes Simplex virus, type 1 (HSV-1) encoding granulocyte-macrophage colony stimulating factor (GM-CSF). T-VEC is adapted for selective replication in melanoma cells and GM-CSF was expressed to augment host anti-tumor immunity. T-VEC is indicated for the local treatment of melanoma recurrent after primary surgery and is the first-in-class oncolytic virus to achieve approval by the FDA in 2015. This review will describe the progress made in advancing T-VEC to the most appropriate melanoma patients, expansion to patients with non-melanoma cancers and clinical trial results of T-VEC combination studies. Further, strategies to identify predictive biomarkers of therapeutic response to T-VEC will be discussed. Finally, a brief outline of high-priority future directions for investigation of T-VEC and other promising oncolytic viruses will set the stage for a best-in-class oncolytic virus to bring the maximum benefit of this emerging class of anti-cancer agents to patients with cancer.
ISSN:2296-889X
2296-889X
DOI:10.3389/fmolb.2022.834841