Fourteen days of smoking cessation improves muscle fatigue resistance and reverses markers of systemic inflammation

Cigarette smoking has a negative effect on respiratory and skeletal muscle function and is a risk factor for various chronic diseases. To assess the effects of 14 days of smoking cessation on respiratory and skeletal muscle function, markers of inflammation and oxidative stress in humans. Spirometry...

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Bibliographic Details
Published in:Scientific reports 2021-06, Vol.11 (1), p.12286-12286, Article 12286
Main Authors: Darabseh, Mohammad Z., Maden-Wilkinson, Thomas M., Welbourne, George, Wüst, Rob C. I., Ahmed, Nessar, Aushah, Hakima, Selfe, James, Morse, Christopher I., Degens, Hans
Format: Article
Language:English
Subjects:
631/443
692/699/1785
Adolescent
Adult
Advanced glycosylation end products
Antioxidants
Biomarkers
Cigarette smoking
Cigarettes
Cytokines - blood
Cytokines - metabolism
Disease Susceptibility
Drug addiction
Fatigue
Female
Glycosylation
Hematocrit
Hemoglobin
Humanities and Social Sciences
Humans
Inflammation
Inflammation - diagnosis
Inflammation - etiology
Inflammation - metabolism
Inflammation Mediators
Interleukin 10
Interleukin 12
Interleukin 2
Interleukin 4
Interleukin 6
Leukocytes (eosinophilic)
Male
Malondialdehyde
multidisciplinary
Muscle Fatigue
Muscle function
Muscle, Skeletal - metabolism
Muscle, Skeletal - physiopathology
Musculoskeletal system
Oxidative Stress
Respiratory Function Tests
Risk Factors
Science
Science (multidisciplinary)
Skeletal muscle
Smoking
Smoking - adverse effects
Smoking Cessation
Time Factors
Tumor necrosis factor-α
Young Adult
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Summary:Cigarette smoking has a negative effect on respiratory and skeletal muscle function and is a risk factor for various chronic diseases. To assess the effects of 14 days of smoking cessation on respiratory and skeletal muscle function, markers of inflammation and oxidative stress in humans. Spirometry, skeletal muscle function, circulating carboxyhaemoglobin levels, advanced glycation end products (AGEs), markers of oxidative stress and serum cytokines were measured in 38 non-smokers, and in 48 cigarette smokers at baseline and after 14 days of smoking cessation. Peak expiratory flow ( p  = 0.004) and forced expiratory volume in 1 s/forced vital capacity ( p  = 0.037) were lower in smokers compared to non-smokers but did not change significantly after smoking cessation. Smoking cessation increased skeletal muscle fatigue resistance ( p  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-91510-x