Antimicrobial Agents Based on Metal Complexes: Present Situation and Future Prospects

The rise in antimicrobial resistance is a cause of serious concern since the ages. Therefore, a dire need to explore new antimicrobial entities that can combat against the increasing threat of antibiotic resistance is realized. Studies have shown that the activity of the strongest antibiotics has re...

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Bibliographic Details
Published in:International journal of biomaterials 2022-12, Vol.2022, p.6819080-21
Main Authors: Sharma, Bharti, Shukla, Sudeep, Rattan, Rohit, Fatima, Musarrat, Goel, Mayurika, Bhat, Mamta, Dutta, Shruti, Ranjan, Rakesh Kumar, Sharma, Mamta
Format: Article
Language:English
Subjects:
Antibiotic resistance
Antibiotics
Antimicrobial agents
Antimicrobial resistance
Bacteria
Coordination compounds
Drug discovery
Drug resistance
Drug resistance in microorganisms
E coli
Enzymes
Gram-negative bacteria
Gram-positive bacteria
Ligands
Malaria
Metal complexes
Metals
Microorganisms
Nanoparticles
Nervous system diseases
Neurodegenerative diseases
Pathogens
Penicillin
Proteins
Review
Silver
Vector-borne diseases
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Summary:The rise in antimicrobial resistance is a cause of serious concern since the ages. Therefore, a dire need to explore new antimicrobial entities that can combat against the increasing threat of antibiotic resistance is realized. Studies have shown that the activity of the strongest antibiotics has reduced drastically against many microbes such as microfungi and bacteria (Gram-positive and Gram-negative). A ray of hope, however, was witnessed in early 1940s with the development of new drug discovery and use of metal complexes as antibiotics. Many new metal-based drugs were developed from the metal complexes which are potentially active against a number of ailments such as cancer, malaria, and neurodegenerative diseases. Therefore, this review is an attempt to describe the present scenario and future development of metal complexes as antibiotics against wide array of microbes.
ISSN:1687-8787
1687-8795
DOI:10.1155/2022/6819080