Opportunities and challenges for the use of deep brain stimulation in the treatment of refractory major depression

Major Depressive Disorder continues to remain one of the most prevalent psychiatric diseases globally. Despite multiple trials of conventional therapies, a subset of patients fail to have adequate benefit to treatment. Deep brain stimulation (DBS) is a promising treatment in this difficult to treat...

Full description

Saved in:
Bibliographic Details
Published in:Discover Mental Health 2024-03, Vol.4 (1), p.9-9, Article 9
Main Authors: Unadkat, Prashin, Quevedo, Joao, Soares, Jair, Fenoy, Albert
Format: Article
Language:English
Subjects:
Antidepressants
Clinical Psychology
Clinical trials
Deep brain stimulation
Electroconvulsive therapy
Electrodes
FDA approval
Medial forebrain bundle
Medicine
Medicine & Public Health
Mental depression
Psychiatry
Psychotherapy
Remission (Medicine)
Resistant depression
Response rates
Review
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Major Depressive Disorder continues to remain one of the most prevalent psychiatric diseases globally. Despite multiple trials of conventional therapies, a subset of patients fail to have adequate benefit to treatment. Deep brain stimulation (DBS) is a promising treatment in this difficult to treat population and has shown strong antidepressant effects across multiple cohorts. Nearly two decades of work have provided insights into the potential for chronic focal stimulation in precise brain targets to modulate pathological brain circuits that are implicated in the pathogenesis of depression. In this paper we review the rationale that prompted the selection of various brain targets for DBS, their subsequent clinical outcomes and common adverse events reported. We additionally discuss some of the pitfalls and challenges that have prevented more widespread adoption of this technology as well as future directions that have shown promise in improving therapeutic efficacy of DBS in the treatment of depression.
ISSN:2731-4383
2731-4383
DOI:10.1007/s44192-024-00062-9