Reduced Serum Levels of Klotho are Associated with Mild Cognitive Impairment in Patients with Type 2 Diabetes Mellitus

The study objective was to investigate the serum levels of Klotho in patients with type 2 diabetes mellitus (T2DM) who had moderate cognitive impairment (MCI) and those without MCI and to determine its prediction of MCI in older patients with T2DM. Patients with diabetes were examined for MCI in 292...

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Published in:Diabetes, metabolic syndrome and obesity metabolic syndrome and obesity, 2023-01, Vol.16, p.129-137
Main Authors: Zhang, Haina, Yu, Lou, Yun, Gai
Format: Article
Language:English
Subjects:
Age
Alzheimer's disease
Analysis
Biomarkers
Body mass index
C-reactive protein
Cardiovascular disease
Cholesterol
Cognitive ability
cognitive impairment (mci)
Creatinine
Dementia
Diabetes
Diabetic retinopathy
Diabetics
Education
Endocrinology
Ethylenediaminetetraacetic acid
Executive function
Gender
Glycosylated hemoglobin
Growth factors
Health care
Hospital patients
Hospitals
Kidneys
klotho
Metabolism
Original Research
Oxidative stress
Public health
Regression analysis
Statistical analysis
Triglycerides
Type 2 diabetes
type 2 diabetes mellitus (t2dm)
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Summary:The study objective was to investigate the serum levels of Klotho in patients with type 2 diabetes mellitus (T2DM) who had moderate cognitive impairment (MCI) and those without MCI and to determine its prediction of MCI in older patients with T2DM. Patients with diabetes were examined for MCI in 292 cases (using the Montreal Cognitive Assessment: MoCA score). Biomarkers and biochemical parameter data were accumulated. Comparing T2DM patients with MCI (91 patients) and without MCI (101 patients), patients with MCI considerably reduced serum Klotho levels were observed. In all 292 hospitalized patients, serum Klotho levels were negatively correlated with age (r=-0.184, P=0.002), body mass index (BMI) (r=-0.151, P=0.010), glycosylated hemoglobin (HbA1c) (r=-0.197, P=0.001), creatinine (r=-0.178, P=0.002), and C-reactive protein (CRP) (r=-0.319, P
ISSN:1178-7007
1178-7007
DOI:10.2147/DMSO.S394099