Recent synthesis of thietanes

Thietanes are important aliphatic four-membered thiaheterocycles that are found in the pharmaceutical core and structural motifs of some biological compounds. They are also useful intermediates in organic synthesis. Various synthetic methods of thietanes have been developed, including inter- and int...

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Bibliographic Details
Published in:Beilstein journal of organic chemistry 2020-06, Vol.16 (1), p.1357-1410
Main Author: Xu, Jiaxi
Format: Article
Language:English
Subjects:
Chemistry
cyclization
cycloaddition
Intermediates
Methods
Review
ring contraction
ring expansion
Sodium
Sulfur
thietane
thiotherification
Vitamin C
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Summary:Thietanes are important aliphatic four-membered thiaheterocycles that are found in the pharmaceutical core and structural motifs of some biological compounds. They are also useful intermediates in organic synthesis. Various synthetic methods of thietanes have been developed, including inter- and intramolecular nucleophilic thioetherifications, photochemical [2 + 2] cycloadditions, ring expansions and contractions, nucleophilic cyclizations, and some miscellaneous methods. The recently developed methods provide some new strategies for the efficient preparation of thietanes and their derivatives. This review focuses on the synthetic methods to construct thietane backbones developed during 1966 to 2019.
ISSN:1860-5397
2195-951X
1860-5397
DOI:10.3762/bjoc.16.116