Evaluation of monocyte to HDL cholesterol ratio and other inflammatory markers in patients with psoriasis

• Published in: Anais brasileiros de dermatología 2020-09, Vol.95 (5), p.575-582
• Main Authors: Sirin, Mumtaz Cem, Korkmaz, Selma, Erturan, Ijlal, Filiz, Basak, Aridogan, Buket Cicioglu, Cetin, Emel Sesli, Yildirim, Mehmet
• Format: Article
• Language: English
• Subjects: Biological markers; Biomarkers; C-Reactive protein; Cholesterol, HDL; Cross-Sectional Studies; DERMATOLOGY; Humans; Inflammation; Investigation; Monocytes; Psoriasis; Serum amyloid A protein
• ISSN: 0365-0596; 1806-4841; 1806-4841
• DOI: 10.1016/j.abd.2020.02.008

Psoriasis is a chronic systemic inflammatory disease frequently associated with serious comorbidities. To investigate the systemic inflammatory burden in psoriasis and to assess the correlation between traditional and novel inflammatory markers and the severity of the disease. This cross-sectional study was conducted on 60 patients with psoriasis vulgaris and 50 healthy volunteers. Data including demographics, Psoriasis Area and Severity Index scores, and laboratory results were analyzed and compared. Compared with the control group, the psoriatic patients had significantly higher high sensitive C-reactive protein, serum amyloid A, erythrocyte sedimentation rate, leukocyte, neutrophil, neutrophil-to-lymphocyte ratio, monocyte to high density lipoprotein (HDL) cholesterol ratio, and aspartate aminotransferase levels, and significantly lower HDL cholesterol levels (p  0.05). The Psoriasis Area and Severity Index score was positively correlated with high-sensitivity C-reactive protein, serum amyloid A, and monocyte to HDL cholesterol ratio, and negatively correlated with lymphocyte-to-monocyte ratio (p