The Position of EGF Deprivation in the Management of Advanced Non-Small Cell Lung Cancer

• Published in: Frontiers in oncology 2021-06, Vol.11, p.639745
• Main Authors: Crombet Ramos, Tania, Santos Morales, Orestes, Dy, Grace K, León Monzón, Kalet, Lage Dávila, Agustín
• Format: Article
• Language: English
• Subjects: CIMAvax-EGF; EGFR; immune checkpoint inhibitors; NSCLC; Oncology; tyrosine kinase inhibitors
• ISSN: 2234-943X; 2234-943X
• DOI: 10.3389/fonc.2021.639745

Advanced non-small cell lung cancer (NSCLC) has faced a therapeutic revolution with the advent of tyrosine kinase inhibitors (TKIs) and immune checkpoints inhibitors (ICIs) approved for first and subsequent therapies. CIMAvax-EGF is a chemical conjugate between human-recombinant EGF and P64, a recombinant protein from , which induces neutralizing antibodies against EGF. In the last 15 years, it has been extensively evaluated in advanced NSCLC patients. CIMAvax-EGF is safe, even after extended use, and able to keep EGF serum concentration below detectable levels. In a randomized phase III study, CIMAvax-EGF increased median overall survival of advanced NSCLC patients with at least stable disease after front-line chemotherapy. Patients bearing squamous-cell or adenocarcinomas and serum EGF concentration above 870 pg/ml had better survival compared to control patients treated with best supportive care as maintenance, confirming tumors' sensitivity to the EGF depletion. This manuscript reviews the state-of-the-art NSCLC therapy and proposes the most promising scenarios for evaluating CIMAvax-EGF, particularly in combination with TKIs or ICIs. We hypothesize that the optimal combination of CIMAvax-EGF with established therapies can further contribute to transform advanced cancer into a manageable chronic disease, compatible with years of good quality of life.