Garcinia mangostana peel extracts exhibit hepatoprotective activity against thioacetamide-induced liver cirrhosis in rats

[Display omitted] •Hepatoprotective effect of Garcinia mangostana is reported using experimental rats.•TAA induced liver cirrhosis assessed immuno/histochemically and biochemically.•Garcinia mangostana significantly down-regulate the PCNA, α-SMA and TGF-β1.•The activities of SOD and CAT considerably...

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Published in:Journal of functional foods 2020-11, Vol.74, p.104200, Article 104200
Main Authors: Abood, Walaa Najm, Bradosty, Sarwan W., Shaikh, Faiyaz Khudaboddin, Salehen, Nur'Ain, Farghadani, Reyhaneh, Agha, Nabaz Fisal Shakir, Al-Medhtiy, Morteta H., Kamil, Treska Dhia Aldeen, Agha, Ali Salim, Abdulla, Mahmood Ameen
Format: Article
Language:English
Subjects:
Garcinia mangostana
Hepatoprotective effect
Liver cirrhosis
Thioacetamide
Traditional therapy
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Summary:[Display omitted] •Hepatoprotective effect of Garcinia mangostana is reported using experimental rats.•TAA induced liver cirrhosis assessed immuno/histochemically and biochemically.•Garcinia mangostana significantly down-regulate the PCNA, α-SMA and TGF-β1.•The activities of SOD and CAT considerably enhanced with decline in MDA level.•The serum level of ALP, ALT, AST, bilirubin and albumin was normal with p 
ISSN:1756-4646
2214-9414
DOI:10.1016/j.jff.2020.104200