Associations of metabolic changes and polygenic risk scores with cardiovascular outcomes and all-cause mortality across BMI categories: a prospective cohort study

Associations between metabolic status and metabolic changes with the risk of cardiovascular outcomes have been reported. However, the role of genetic susceptibility underlying these associations remains unexplored. We aimed to examine how metabolic status, metabolic transitions, and genetic suscepti...

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Bibliographic Details
Published in:Cardiovascular diabetology 2024-07, Vol.23 (1), p.231-17, Article 231
Main Authors: Li, Cancan, Meng, Xiaoni, Zhang, Jie, Wang, Haotian, Lu, Huimin, Cao, Meiling, Sun, Shengzhi, Wang, Youxin
Format: Article
Language:English
Subjects:
Adult
Aged
All-cause mortality
Biobanks
Blood pressure
Body Mass Index
Body weight
Cardiometabolic Risk Factors
Cardiovascular disease
Cardiovascular diseases
Cardiovascular Diseases - diagnosis
Cardiovascular Diseases - epidemiology
Cardiovascular Diseases - genetics
Cardiovascular Diseases - mortality
Cause of Death
Cholesterol
Education
Educational attainment
Exercise
Family income
Female
Genetic diversity
Genetic Predisposition to Disease
Genetic Risk Score
Health risk assessment
Health risks
High density lipoprotein
Humans
Job requirements
Male
Metabolic change
Metabolic health
Metabolic syndrome
Metabolism
Middle Aged
Morbidity
Mortality
Multifactorial Inheritance
Obesity
Obesity - diagnosis
Obesity - epidemiology
Obesity - genetics
Obesity - mortality
Obesity, Metabolically Benign - diagnosis
Obesity, Metabolically Benign - epidemiology
Obesity, Metabolically Benign - genetics
Obesity, Metabolically Benign - mortality
Overweight
Phenotype
Polygenic risk scores
Prognosis
Prospective Studies
Questionnaires
Regression analysis
Risk Assessment
Risk Factors
Secondary education
Socioeconomic factors
Socioeconomic status
Stroke
Time Factors
Triglycerides
United Kingdom - epidemiology
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Description
Summary:Associations between metabolic status and metabolic changes with the risk of cardiovascular outcomes have been reported. However, the role of genetic susceptibility underlying these associations remains unexplored. We aimed to examine how metabolic status, metabolic transitions, and genetic susceptibility collectively impact cardiovascular outcomes and all-cause mortality across diverse body mass index (BMI) categories. In our analysis of the UK Biobank, we included a total of 481,576 participants (mean age: 56.55; male: 45.9%) at baseline. Metabolically healthy (MH) status was defined by the presence of
ISSN:1475-2840
1475-2840
DOI:10.1186/s12933-024-02332-w