Electroconvulsive Therapy Modulates Resting-State EEG Oscillatory Pattern and Phase Synchronization in Nodes of the Default Mode Network in Patients With Depressive Disorder

: Electroconvulsive therapy (ECT) has antidepressant effects, but it also has possible cognitive side effects. The effects of ECT on neuronal oscillatory pattern and phase synchronization, and the relationship between clinical response or cognitive change and electroencephalogram (EEG) measurements...

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Bibliographic Details
Published in:Frontiers in human neuroscience 2019-02, Vol.13, p.1-1
Main Authors: Takamiya, Akihiro, Hirano, Jinichi, Yamagata, Bun, Takei, Shigeki, Kishimoto, Taishiro, Mimura, Masaru
Format: Article
Language:English
Subjects:
Cognitive ability
Convulsions & seizures
Cortex (cingulate)
Cortex (frontal)
current source density
depressive disorder
EEG
Electroconvulsive therapy
Electrodes
Electroencephalography
Family medical history
Hemispheric laterality
Hospitals
Lead
low resolution electromagnetic tomography
Medicine
Mental depression
Neuroscience
NMR
Nuclear magnetic resonance
phase synchronization
Psychiatry
Side effects
Studies
Synchronization
Systematic review
Temporal cortex
Tomography
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Summary:: Electroconvulsive therapy (ECT) has antidepressant effects, but it also has possible cognitive side effects. The effects of ECT on neuronal oscillatory pattern and phase synchronization, and the relationship between clinical response or cognitive change and electroencephalogram (EEG) measurements remain elusive. : Individuals with unipolar depressive disorder receiving bilateral ECT were recruited. Five minutes of resting, eyes-closed, 19-lead EEG recordings were obtained before and after a course of ECT. Non-overlapping 60 artifact-free epocs of 2-s duration were used for the analyses. We used exact low resolution electromagnetic tomography (eLORETA) to compute the whole-brain three-dimensional intracortical distribution of current source density (CSD) and phase synchronization among 28 regions-of-interest (ROIs). Paired -tests were used to identify cortical voxels and connectivities showing changes after ECT. Montgomery Asberg Depression Rating Scale (MADRS) and Mini-Mental State Examination (MMSE) were used to evaluate the severity of depression and the global cognitive function. Correlation analyses were conducted to identify the relationship between changes in the EEG measurements and changes in MADRS or MMSE. : Thirteen depressed patients (five females, mean age: 58.4 years old) were included. ECT increased theta CSD in the anterior cingulate cortex (ACC), and decreased beta CSD in the frontal pole (FP), and gamma CSD in the inferior parietal lobule (IPL). ECT increased theta phase synchronization between the posterior cingulate cortex (PCC) and the anterior frontal cortex, and decreased beta phase synchronization between the PCC and temporal regions. A decline in beta synchronization in the left hemisphere was associated with cognitive changes after ECT. : ECT modulated resting-state EEG oscillatory patterns and phase synchronization in central nodes of the default mode network (DMN). Changes in beta synchronization in the left hemisphere might explain the ECT-related cognitive side effects.
ISSN:1662-5161
1662-5161
DOI:10.3389/fnhum.2019.00001