Potential of Viruses as Environmental Etiological Factors for Non-Syndromic Orofacial Clefts

In this study, we analyzed the potential of viral infections in the species as environmental causes of orofacial clefts (OFCs). A scoring system was adapted for qualitatively assessing the potential of viruses to cause cleft lip and/or palate (CL/P). This assessment considered factors such as inform...

Full description

Saved in:
Bibliographic Details
Published in:Viruses 2024-04, Vol.16 (4), p.511
Main Authors: Messias, Thiago S, Silva, Kaique C P, Silva, Thiago C, Soares, Simone
Format: Article
Language:English
Subjects:
Amino acids
Analysis
Animals
Biotechnology
Birth defects
Causes and theories of causation
Cleft lip
Cleft Lip - virology
Cleft lip/palate
Cleft palate
Cleft Palate - virology
Coronaviruses
Cytomegalovirus
Development and progression
Diseases
etiology
Genetic aspects
Genomes
Health aspects
Hominids
Humans
Infection
Infections
Lymphocytic choriomeningitis
Monkeys & apes
mosquito-borne viruses
Mpox
Nonparametric statistics
Orofacial clefts
pathogenesis
Software
Statistical analysis
Viral infections
Virology
Virus Diseases - virology
Viruses
Viruses - classification
Viruses - genetics
Viruses - isolation & purification
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In this study, we analyzed the potential of viral infections in the species as environmental causes of orofacial clefts (OFCs). A scoring system was adapted for qualitatively assessing the potential of viruses to cause cleft lip and/or palate (CL/P). This assessment considered factors such as information from the literature, nucleotide and amino acid similarities, and the presence of Endogenous Viral Elements (EVEs). The analysis involved various algorithm packages within Basic Local Alignment Search Tool 2.13.0 software and databases from the National Center for Biotechnology Information and the International Committee on Taxonomy of Viruses. Twenty significant viral species using different biosynthesis strategies were identified: , , , , , , , , , , , , , , , , , , , and . The evident viral etiological potential in relation to CL/P varies depending on the Baltimore class to which the viral species belongs. Given the multifactorial nature of CL/P, this relationship appears to be dynamic.
ISSN:1999-4915
1999-4915
DOI:10.3390/v16040511