Effect of application of fibrin glue on vocal fold healing after surgical manipulation in rabbits

•Evaluation of prophylactic effect of sealants in laryngeal surgeries that require extensive detachment of the vocal fold cover Prophylactic effect of sealants in laryngeal surgeries.•Incision over the entire length of the vocal fold, followed by anterior and posterior sectioning of the mucosa, crea...

Full description

Saved in:
Bibliographic Details
Published in:Brazilian journal of otorhinolaryngology 2022-11, Vol.88 (Suppl 1), p.S102-S107
Main Authors: Santos, Fernanda da Silva, Ikeda, Felipe Hideo, Barros, Mirna Duarte, Duprat, André de Campos
Format: Article
Language:English
Subjects:
Animals
Collagen
Fibrin Tissue Adhesive
Fibrosis
Larynx
Male
Original
OTORHINOLARYNGOLOGY
Prospective Studies
Rabbits
Vocal cords
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:•Evaluation of prophylactic effect of sealants in laryngeal surgeries that require extensive detachment of the vocal fold cover Prophylactic effect of sealants in laryngeal surgeries.•Incision over the entire length of the vocal fold, followed by anterior and posterior sectioning of the mucosa, creating a pedicled flap. Extensive detachment of the vocal fold cover creating a pedicled flap.•Fibrin glue induced greater fibrogenesis in the vocal fold in a later stage of the healing process. Fibrin glue induced greater fibrogenesis in the vocal fold. A challenge in phonosurgery is achieving good vocal quality with minimal vocal fold fibrosis. Fibrin glue can be applied to minimize fibrosis; however, its use in the larynx is based primarily on clinical experience, particularly in extensive lesions. The objective of this study was to evaluate the effect of application of fibrin glue on collagen concentration at the late phase of the healing process after detaching a pedicled flap of the vocal fold cover in rabbits. In this prospective animal study, twelve adult male rabbits underwent laryngeal microsurgery, in which an incision was made along the entire length of both vocal folds, followed by extensive mucosal detachment and section of the incision ends. Fibrin glue was applied in the left vocal fold, and the mucosa was repositioned. In the right vocal fold, the mucosa was repositioned without treatment with fibrin glue. After 3-months, the rabbits were euthanized. Histological analyses were performed, and the data collected were subjected to statistical analysis. Vocal folds treated with fibrin glue presented higher collagen concentration in Masson trichrome staining and significantly higher (p 
ISSN:1808-8694
1808-8686
1808-8686
DOI:10.1016/j.bjorl.2021.04.005