Ion Channels in Pulmonary Hypertension: A Therapeutic Interest?

Pulmonary arterial hypertension (PAH) is a multifactorial and severe disease without curative therapies. PAH pathobiology involves altered pulmonary arterial tone, endothelial dysfunction, distal pulmonary vessel remodeling, and inflammation, which could all depend on ion channel activities (K⁺, Ca...

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Bibliographic Details
Published in:International journal of molecular sciences 2018-10, Vol.19 (10), p.3162
Main Authors: Lambert, Mélanie, Capuano, Véronique, Olschewski, Andrea, Sabourin, Jessica, Nagaraj, Chandran, Girerd, Barbara, Weatherald, Jason, Humbert, Marc, Antigny, Fabrice
Format: Article
Language:English
Subjects:
Animals
Antihypertensive Agents - pharmacology
Antihypertensive Agents - therapeutic use
Gene Expression Regulation - drug effects
Humans
Hypertension, Pulmonary - drug therapy
Hypertension, Pulmonary - metabolism
Ion Channels - metabolism
K+ channels
KCNK3
Life Sciences
Na+ channels
Orai
PAH
pulmonary hypertension
Review
TMEM16A
TRPC
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Summary:Pulmonary arterial hypertension (PAH) is a multifactorial and severe disease without curative therapies. PAH pathobiology involves altered pulmonary arterial tone, endothelial dysfunction, distal pulmonary vessel remodeling, and inflammation, which could all depend on ion channel activities (K⁺, Ca , Na⁺ and Cl ). This review focuses on ion channels in the pulmonary vasculature and discusses their pathophysiological contribution to PAH as well as their therapeutic potential in PAH.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms19103162