Survival in a pediatric patient with cerebral aspergillosis: A case report

Aspergillosis is an infrequent infection in the Central Nervous System with a mortality rate higher than 95 %. Early diagnosis is challenging and crucial. In this report, we present the case of a six-year-old female with an intense headache accompanied by left hemiparesis, gaze deviation, horizontal...

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Bibliographic Details
Published in:IDCases 2024, Vol.36, p.e01948, Article e01948
Main Authors: Ramírez-Acosta, Ana Paula, Acosta-Yebra, Lilian Danae, Macedo-Montero, Mariela Guadalupe, Flores-Vargas, Gilberto, Padilla-Raygoza, Nicolás
Format: Article
Language:English
Subjects:
Amphotericin B
Aspergillosis
Biopsy
Case report
Central nervous system
Polymerase chain reaction
Sequalae
Survival
Voriconazole
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Summary:Aspergillosis is an infrequent infection in the Central Nervous System with a mortality rate higher than 95 %. Early diagnosis is challenging and crucial. In this report, we present the case of a six-year-old female with an intense headache accompanied by left hemiparesis, gaze deviation, horizontal nystagmus, and vomiting of mucous content on five occasions. After several approaches, a cerebrospinal fluid PCR resulted positive for Aspergillus spp., and then management started with amphotericin B at 2.6 mg/kg/day and was managed to have voriconazole. She survived, and two years after her first hospital admission, she suffered from cerebral aspergillosis sequelae. An area of improvement is the coordination between the request and delivery of studies outside the institution. In this case, the patient´s mother did not report the analysis results on time, delaying the diagnosis.
ISSN:2214-2509
2214-2509
DOI:10.1016/j.idcr.2024.e01948