Monoclonal Antibodies against Plasmodium falciparum Circumsporozoite Protein

Malaria is a mosquito-borne infectious disease caused by the parasite Plasmodium spp. Malaria continues to have a devastating impact on human health. Sporozoites are the infective forms of the parasite inside mosquito salivary glands. Circumsporozoite protein (CSP) is a major and immunodominant prot...

Full description

Saved in:
Bibliographic Details
Published in:Antibodies (Basel) 2017-08, Vol.6 (3), p.11
Main Authors: Zhang, Min, Mandraju, Rajakumar, Rai, Urvashi, Shiratsuchi, Takayuki, Tsuji, Moriya
Format: Article
Language:English
Subjects:
2A10
3C1
3C2
3D3
Aquatic insects
Circumsporozoite protein
CSP
Erythrocytes
Glands
Immunoglobulins
Infectious diseases
Malaria
Monoclonal antibodies
monoclonal antibody
Mosquitoes
Parasites
Plasmodium
Plasmodium falciparum
Protective antigen
Salivary glands
Sporozoites
Vector-borne diseases
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Malaria is a mosquito-borne infectious disease caused by the parasite Plasmodium spp. Malaria continues to have a devastating impact on human health. Sporozoites are the infective forms of the parasite inside mosquito salivary glands. Circumsporozoite protein (CSP) is a major and immunodominant protective antigen on the surface of Plasmodium sporozoites. Here, we report a generation of specific monoclonal antibodies that recognize the central repeat and C-terminal regions of P. falciparum CSP. The monoclonal antibodies 3C1, 3C2, and 3D3-specific for the central repeat region-have higher titers and protective efficacies against challenge with sporozoites compared with 2A10, a gold standard monoclonal antibody that was generated in early 1980s.
ISSN:2073-4468
2073-4468
DOI:10.3390/antib6030011