A systematic review for the development of Alzheimer's disease in in vitro models: a focus on different inducing agents

Alzheimer's disease (AD) is the most common progressive neurodegenerative disease and is associated with dementia. Presently, various chemical and environmental agents are used to induce models of Alzheimer disease to investigate the efficacy of different therapeutic drugs. We screened literatu...

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Bibliographic Details
Published in:Frontiers in aging neuroscience 2023-12, Vol.15, p.1296919-1296919
Main Authors: Prajapat, Manisha, Kaur, Gurjeet, Choudhary, Gajendra, Pahwa, Paras, Bansal, Seema, Joshi, Rupa, Batra, Gitika, Mishra, Abhishek, Singla, Rubal, Kaur, Harminder, Prabha, Praisy K, Patel, Ajay Prakash, Medhi, Bikash
Format: Article
Language:English
Subjects:
Aging Neuroscience
Alzheimer's disease
amyloid beta
Cell culture
Clinical trials
Dementia
Dementia disorders
Disease
Enzymes
Hypotheses
in-vitro models
Kinases
Mutation
Neurodegeneration
Neurodegenerative diseases
Pathogenesis
Pathophysiology
Phosphorylation
Proteins
Systematic review
tau protein
Toxicity
Transgenic animals
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Summary:Alzheimer's disease (AD) is the most common progressive neurodegenerative disease and is associated with dementia. Presently, various chemical and environmental agents are used to induce models of Alzheimer disease to investigate the efficacy of different therapeutic drugs. We screened literature from databases such as PubMed, ScienceDirect, and Google scholar, emphasizing the diverse targeting mechanisms of neuro degeneration explored in models. The results revealed studies in which different types of chemicals and environmental agents were used for development of Alzheimer-targeting mechanisms of neurodegeneration. Studies using chemically induced AD models included in this systematic review will contribute to a deeper understanding of AD. However, none of these models can reproduce all the characteristics of disease progression seen in the majority of Alzheimer's disease subtypes. Additional modifications would be required to replicate the complex conditions of human AD in an exact manner. models of Alzheimer's disease developed using chemicals and environmental agents are instrumental in providing insights into the disease's pathophysiology; therefore, chemical-induced AD models will continue to play vital role in future AD research. This systematic screening revealed the pivotal role of chemical-induced AD models in advancing our understanding of AD pathophysiology and is therefore important to understand the potential of these chemicals in AD pathogenesis.
ISSN:1663-4365
1663-4365
DOI:10.3389/fnagi.2023.1296919