Systematic Assessment of Immune Marker Variation in Type 1 Diabetes: A Prospective Longitudinal Study

Immune analytes have been widely tested in efforts to understand the heterogeneity of disease progression, risk, and therapeutic responses in type 1 diabetes (T1D). The future clinical utility of such analytes as biomarkers depends on their technical and biological variability, as well as their corr...

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Bibliographic Details
Published in:Frontiers in immunology 2019-09, Vol.10, p.2023-2023
Main Authors: Speake, Cate, Bahnson, Henry T, Wesley, Johnna D, Perdue, Nikole, Friedrich, David, Pham, Minh N, Lanxon-Cookson, Erinn, Kwok, William W, Sehested Hansen, Birgit, von Herrath, Matthias, Greenbaum, Carla J
Format: Article
Language:English
Subjects:
clinical trials
immune assays
Immunology
insulin secretion
type 1 diabetes
variability
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Summary:Immune analytes have been widely tested in efforts to understand the heterogeneity of disease progression, risk, and therapeutic responses in type 1 diabetes (T1D). The future clinical utility of such analytes as biomarkers depends on their technical and biological variability, as well as their correlation with clinical outcomes. To assess the variability of a panel of 91 immune analytes, we conducted a prospective study of adults with T1D (
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2019.02023