Meta-analysis of exome array data identifies six novel genetic loci for lung function

• Published in: Wellcome open research 2018-06, Vol.3, p.4
• Main Authors: Jackson, Victoria E., Latourelle, Jeanne C., Wain, Louise V., Smith, Albert V., Grove, Megan L., Bartz, Traci M., Obeidat, Ma'en, Province, Michael A., Gao, Wei, Qaiser, Beenish, Porteous, David J., Cassano, Patricia A., Ahluwalia, Tarunveer S., Grarup, Niels, Li, Jin, Altmaier, Elisabeth, Marten, Jonathan, Harris, Sarah E., Manichaikul, Ani, Pottinger, Tess D., Li-Gao, Ruifang, Lind-Thomsen, Allan, Mahajan, Anubha, Lahousse, Lies, Imboden, Medea, Teumer, Alexander, Prins, Bram, Lyytikäinen, Leo-Pekka, Eiriksdottir, Gudny, Franceschini, Nora, Sitlani, Colleen M., Brody, Jennifer A., Bossé, Yohan, Timens, Wim, Kraja, Aldi, Loukola, Anu, Tang, Wenbo, Liu, Yongmei, Bork-Jensen, Jette, Justesen, Johanne M., Linneberg, Allan, Lange, Leslie A., Rawal, Rajesh, Karrasch, Stefan, Huffman, Jennifer E., Smith, Blair H., Davies, Gail, Burkart, Kristin M., Mychaleckyj, Josyf C., Bonten, Tobias N., Enroth, Stefan, Lind, Lars, Brusselle, Guy G., Kumar, Ashish, Stubbe, Beate, Kähönen, Mika, Wyss, Annah B., Psaty, Bruce M., Heckbert, Susan R., Hao, Ke, Rantanen, Taina, Kritchevsky, Stephen B., Lohman, Kurt, Skaaby, Tea, Pisinger, Charlotta, Hansen, Torben, Schulz, Holger, Polasek, Ozren, Campbell, Archie I., Starr, John M., Rich, Stephen S., Mook-Kanamori, Dennis O., Johansson, Åsa, Ingelsson, Erik, Uitterlinden, André G., Weiss, Stefan, Raitakari, Olli T., Gudnason, Vilmundur, North, Kari E., Gharib, Sina A., Sin, Don D., Taylor, Kent D., O'Connor, George T., Kaprio, Jaakko, Harris, Tamara B., Pederson, Oluf, Vestergaard, Henrik, Wilson, James G., Strauch, Konstantin, Hayward, Caroline, Kerr, Shona M., Deary, Ian J., Barr, R. Graham, de Mutsert, Renée, Gyllensten, Ulf, Morris, Andrew P., Ikram, M. Arfan, Probst-Hensch, Nicole, Gläser, Sven, Zeggini, Eleftheria
• Format: Article
• Language: English
• Subjects: Genomics
• ISSN: 2398-502X; 2398-502X
• DOI: 10.12688/wellcomeopenres.12583.2

Background: Over 90 regions of the genome have been associated with lung function to date, many of which have also been implicated in chronic obstructive pulmonary disease. Methods: We carried out meta-analyses of exome array data and three lung function measures: forced expiratory volume in one second (FEV 1 ), forced vital capacity (FVC) and the ratio of FEV 1 to FVC (FEV 1 /FVC). These analyses by the SpiroMeta and CHARGE consortia included 60,749 individuals of European ancestry from 23 studies, and 7,721 individuals of African Ancestry from 5 studies in the discovery stage, with follow-up in up to 111,556 independent individuals. Results: We identified significant (P