Anaplastic large cell lymphoma with ALK::ATIC fusion mimicking a histiocytic sarcoma debuting as an anterior thoracic soft tissue tumor with exceptional clinicopathological, morphological and molecular features

A 56‐year‐old woman debuted with a palpable painless mass in the anterior thorax wall at the level of the second and third right parasternal intercostal space, which progressively increased in size over 5 months accompanied by localized skin rash, mild dyspnea and chest pain when changing position....

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Bibliographic Details
Published in:Thoracic cancer 2024-05, Vol.15 (13), p.1103-1105
Main Authors: García‐Muñiz, José Antonio, Vilches‐Cisneros, Natalia, Flores‐Gutiérrez, Juan Pablo, Barboza‐Quintana, Oralia
Format: Article
Language:English
Subjects:
ALCL
ALK::ATIC
Anaplastic Lymphoma Kinase - genetics
Biopsy
Case Report
Case Reports
Conflicts of interest
Diagnosis, Differential
Dyspnea
FDA approval
Female
histiocytic sarcoma
Histiocytic Sarcoma - genetics
Histiocytic Sarcoma - pathology
Histology
Humans
Lymphoma
Lymphoma, Large-Cell, Anaplastic - diagnosis
Lymphoma, Large-Cell, Anaplastic - genetics
Lymphoma, Large-Cell, Anaplastic - pathology
Medical imaging
Middle Aged
Morphology
NGS
Pathology
Sarcoma
Soft Tissue Neoplasms - genetics
Soft Tissue Neoplasms - pathology
Thoracic Neoplasms - genetics
Thoracic Neoplasms - pathology
Tomography
Tumors
Citations: Items that this one cites
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Description
Summary:A 56‐year‐old woman debuted with a palpable painless mass in the anterior thorax wall at the level of the second and third right parasternal intercostal space, which progressively increased in size over 5 months accompanied by localized skin rash, mild dyspnea and chest pain when changing position. Imaging studies showed a soft tissue mass measuring 75 × 62 mm and a density of 34 Hounsfield Units that had caused the lysis of the costal arches and grew expansively towards the anterior mediastinum, without identifying mediastinal adenopathies only by this imaging method. Core biopsy was performed, which was initially diagnosed as histiocytic sarcoma (HS); however, when the diagnostic panel was expanded to include molecular and NGS studies, the final diagnosis was anaplastic large cell lymphoma with ALK::ATIC fusion. Here, we report a very rare neoplasm with unusual clinical presentation, histopathology and molecular features.
ISSN:1759-7706
1759-7714
DOI:10.1111/1759-7714.15293