KLF10 integrates circadian timing and sugar signaling to coordinate hepatic metabolism

The mammalian circadian timing system and metabolism are highly interconnected, and disruption of this coupling is associated with negative health outcomes. Krüppel-like factors (KLFs) are transcription factors that govern metabolic homeostasis in various organs. Many KLFs show a circadian expressio...

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Bibliographic Details
Published in:eLife 2021-08, Vol.10
Main Authors: Ruberto, Anthony A, Gréchez-Cassiau, Aline, Guérin, Sophie, Martin, Luc, Revel, Johana S, Mehiri, Mohamed, Subramaniam, Malayannan, Delaunay, Franck, Teboul, Michèle
Format: Article
Language:English
Subjects:
Cell Biology
Circadian rhythm
Circadian rhythms
Energy metabolism
Fatty liver
Food
fructose
Gene expression
Genomics
glucose
Glucose tolerance
Hepatocytes
Homeostasis
Intolerance
krüppel like factors
Liver
Metabolism
Metabolites
Physiology
Rodents
Steatosis
Sugar
Transcription factors
Transcriptomes
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Summary:The mammalian circadian timing system and metabolism are highly interconnected, and disruption of this coupling is associated with negative health outcomes. Krüppel-like factors (KLFs) are transcription factors that govern metabolic homeostasis in various organs. Many KLFs show a circadian expression in the liver. Here, we show that the loss of the clock-controlled KLF10 in hepatocytes results in extensive reprogramming of the mouse liver circadian transcriptome, which in turn alters the temporal coordination of pathways associated with energy metabolism. We also show that glucose and fructose induce Klf10, which helps mitigate glucose intolerance and hepatic steatosis in mice challenged with a sugar beverage. Functional genomics further reveal that KLF10 target genes are primarily involved in central carbon metabolism. Together, these findings show that in the liver KLF10 integrates circadian timing and sugar metabolism-related signaling, and serves as a transcriptional brake that protects against the deleterious effects of increased sugar consumption.
ISSN:2050-084X
2050-084X
DOI:10.7554/eLife.65574