Obesity and risk of respiratory tract infections: results of an infection-diary based cohort study

• Published in: BMC public health 2018-02, Vol.18 (1), p.271-271, Article 271
• Main Authors: Maccioni, Livia, Weber, Susanne, Elgizouli, Magdeldin, Stoehlker, Anne-Sophie, Geist, Ilona, Peter, Hans-Hartmut, Vach, Werner, Nieters, Alexandra
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Adult respiratory tract infections; Adults; Aged; Antibiotics; Asthma; Body mass index; Bronchitis; Cohort analysis; Cohort Studies; Community; Complications and side effects; Cross-Sectional Studies; Demographic variables; Demographics; Diaries; Diary; Ear diseases; Effect modification; Exercise; Female; Gender; Germany - epidemiology; Humans; Illnesses; Immunology; Infections; Influenza; Life style factors; Male; Medical research; Middle Aged; Morbidity; Obesity; Obesity - epidemiology; Physical fitness; Pneumonia; Population; Public health; Quality of life; Respiratory tract; Respiratory tract diseases; Respiratory tract infection; Respiratory tract infections; Respiratory Tract Infections - epidemiology; Risk analysis; Risk Factors; Seasons; Self Report; Statistical analysis; Studies; Systematic review; Tonsillitis; Viral infections; Young Adult
• ISSN: 1471-2458; 1471-2458
• DOI: 10.1186/s12889-018-5172-8

Respiratory tract infections (RTIs) are a major morbidity factor contributing largely to health care costs and individual quality of life. The aim of the study was to test whether obesity (BMI ≥ 30 kg/m ) is one of the risk factors underlying frequent RTIs in the German adult population. We recruited 1455 individuals between 18 to 70 years from a cross-sectional survey on airway infections in Germany and invited them to self-report in diaries incident RTIs experienced during three consecutive winter/spring seasons. RTIs reported in these 18 months and summary measures adding-up individual RTIs were the outcomes of interest. Compared to individuals with normal weight, obese individuals reported a consistently higher frequency of upper and lower RTIs and predominantly fell in the upper 10% group of a diary sumscore adding-up 10 different RTI symptoms over time. Obesity was associated both with lower RTIs ( OR = 2.02, 95%CI = 1.36-3.00) and upper RTIs ( OR = 1.55, 95%CI = 1.22-1.96). Adjusting for demographic and lifestyle variables did only marginally affect ORs. Stratified analyses suggested a stronger association for women and effect modifications by sports activity and dietary habits. We confirm the association of obesity with infection burden and present evidence for putative interaction with sports activity and dietary patterns.