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Background: Urinary lipoarabinomannan (LAM) detection is a promising approach for the rapid diagnosis of active tuberculosis (TB). Objective: To assess the diagnostic accuracy of urine LAM among TB patients either pulmonary or extra pulmonary. Methods: This study was carried out on 85 cases (46 male...

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Bibliographic Details
Published in:The Egyptian journal of chest diseases and tuberculosis 2013-07, Vol.62 (3), p.401-407
Main Authors: Mohammed A. Agha, Rana H. El-Helbawy, Nessrin G. El-Helbawy, Neveen M. El-Sheak
Format: Article
Language:English
Subjects:
ELISA
Lipoarabinomannan
Tuberculosis
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Summary:Background: Urinary lipoarabinomannan (LAM) detection is a promising approach for the rapid diagnosis of active tuberculosis (TB). Objective: To assess the diagnostic accuracy of urine LAM among TB patients either pulmonary or extra pulmonary. Methods: This study was carried out on 85 cases (46 male and 39 female) with active tubercular infection divided into three groups; pulmonary (n = 40), extra pulmonary (n = 30) and disseminated tuberculosis (n = 15). Twenty-five normal individuals were included as the control group. LAM level was measured in urine by enzyme-linked immunosorbant assay (ELISA). Results: TB Patients with disseminated disease had a higher urine LAM level (1.75 ± 1.65 ng/ml) than that for patients with pulmonary (0.58 ± 0.53 ng/ml) or extra pulmonary TB (0.17 ± 0.11 ng/ml) (P 
ISSN:0422-7638
DOI:10.1016/j.ejcdt.2013.06.007