Chronic exposure to deoxynivalenol has no influence on the oral bioavailability of fumonisin B1 in broiler chickens

Both deoxynivalenol (DON) and fumonisin B1 (FB1) are common contaminants of feed. Fumonisins (FBs) in general have a very limited oral bioavailability in healthy animals. Previous studies have demonstrated that chronic exposure to DON impairs the intestinal barrier function and integrity, by affecti...

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Bibliographic Details
Published in:Toxins 2015-02, Vol.7 (2), p.560-571
Main Authors: Antonissen, Gunther, Devreese, Mathias, Van Immerseel, Filip, De Baere, Siegrid, Hessenberger, Sabine, Martel, An, Croubels, Siska
Format: Article
Language:English
Subjects:
Administration, Oral
Animal Feed - analysis
Animal Feed - toxicity
Animals
Area Under Curve
Bioavailability
Biological Availability
broiler chickens
Chickens
Chickens - growth & development
Communication
Contaminants
Data Interpretation, Statistical
deoxynivalenol
Exposure
Female
Food Contamination - analysis
fumonisin B1
Fumonisins - blood
Fumonisins - pharmacokinetics
Fumonisins - toxicity
Fusarium toxins
Intestinal Absorption - drug effects
Male
Mycotoxins
oral bioavailability
toxicokinetics
Trichothecenes - blood
Trichothecenes - toxicity
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Summary:Both deoxynivalenol (DON) and fumonisin B1 (FB1) are common contaminants of feed. Fumonisins (FBs) in general have a very limited oral bioavailability in healthy animals. Previous studies have demonstrated that chronic exposure to DON impairs the intestinal barrier function and integrity, by affecting the intestinal surface area and function of the tight junctions. This might influence the oral bioavailability of FB1, and possibly lead to altered toxicity of this mycotoxin. A toxicokinetic study was performed with two groups of 6 broiler chickens, which were all administered an oral bolus of 2.5 mg FBs/kg BW after three-week exposure to either uncontaminated feed (group 1) or feed contaminated with 3.12 mg DON/kg feed (group 2). No significant differences in toxicokinetic parameters of FB1 could be demonstrated between the groups. Also, no increased or decreased body exposure to FB1 was observed, since the relative oral bioavailability of FB1 after chronic DON exposure was 92.2%.
ISSN:2072-6651
2072-6651
DOI:10.3390/toxins7020560