Vortex-Assisted Dispersive Molecularly Imprinted Polymer-Based Solid Phase Extraction of Acetaminophen from Water Samples Prior to HPLC-DAD Determination

In the present study, acetaminophen (ACT) molecularly imprinted polymer (ACT-MIP) were successfully synthesized via surface imprinting polymerization. The structural and morphological properties of ACT-MIP were characterized using various analytical techniques. ACT-MIP were used as an adsorbent in a...

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Bibliographic Details
Published in:Separations 2021-10, Vol.8 (10), p.194
Main Authors: Mpayipheli, Neliswa, Mpupa, Anele, Nomngongo, Philiswa Nosizo
Format: Article
Language:English
Subjects:
acetaminophen
Acids
Adsorbents
Adsorption
adsorption isotherms
Analgesics
Chromatography
Design of experiments
Desorption
Dispersion
Ethanol
Fourier transforms
High performance liquid chromatography
Imprinted polymers
Mass spectrometry
Mathematical analysis
Microscopy
molecularly imprinted polymer
Pharmaceuticals
Polymers
Scatchard analysis
Scientific imaging
selectivity
Silicones
Solid phases
solid-phase microextraction
Vortices
Water sampling
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Summary:In the present study, acetaminophen (ACT) molecularly imprinted polymer (ACT-MIP) were successfully synthesized via surface imprinting polymerization. The structural and morphological properties of ACT-MIP were characterized using various analytical techniques. ACT-MIP were used as an adsorbent in a vortex-assisted dispersive molecularly imprinted solid-phase micro-extraction (VA-d-μ-MISPE), coupled with a high-performance liquid chromatography–diode array detector (HPLC-DAD) method for the determination of ACT in water samples. Influential parameters such as the mass of adsorbent, vortex speed, extraction time, desorption volume, and desorption time were optimized using a multivariate approach. Under optimum conditions, the maximum binding capacities of ACT-MIP and NIP (non-imprinted polymers) were 191 mg/g and 71.5 mg/g, respectively. The linearity was attained across concentrations ranging from 0.630 to 500 µg/L, with a coefficient of determination of 0.9959. For ACT-MIP, the limit of detection (LOD) and limit of quantification (LOQ), enhancement factor, and precision of the method were 0.19 ng/L, 0.63 ng/L, 79, and
ISSN:2297-8739
2297-8739
DOI:10.3390/separations8100194