Topical Dosage Formulation of Lyophilized Philadelphus coronarius L. Leaf and Flower: Antimicrobial, Antioxidant and Anti-Inflammatory Assessment of the Plant

• Published in: Molecules (Basel, Switzerland) Switzerland), 2022-04, Vol.27 (9), p.2652
• Main Authors: Pető, Ágota, Kósa, Dóra, Haimhoffer, Ádám, Nemes, Dániel, Fehér, Pálma, Ujhelyi, Zoltán, Vecsernyés, Miklós, Váradi, Judit, Fenyvesi, Ferenc, Frum, Adina, Gligor, Felicia Gabriela, Vicaș, Laura Grațiela, Marian, Eleonora, Jurca, Tunde, Pallag, Annamaria, Muresan, Mariana Eugenia, Tóth, Zoltán, Bácskay, Ildikó
• Format: Article
• Language: English
• Subjects: Anti-Bacterial Agents - pharmacology; Anti-Infective Agents - pharmacology; Anti-inflammatory agents; Anti-Inflammatory Agents - pharmacology; Antiinfectives and antibacterials; Antimicrobial agents; Antioxidants; Antioxidants - pharmacology; Bioactive compounds; Bioavailability; Biocompatibility; chemical compounds; Chemical elements; cytotoxicity; Drug dosages; E coli; Enzymes; Experiments; Flavonoids; Flowers; Folk medicine; Herbs; Inflammation; Interleukin 4; Leaves; Medical research; Ointments; penetration enhancers; Pharmaceuticals; Philadelphus coronarius; Plant Extracts - pharmacology; Plant Leaves; Texture; Topical application
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules27092652

is a versatile plant and its use in folk medicine has a long tradition; however, scientifically, the medical utilization of the herb is a less explored research field. The aim of our study was to identify and determine the quantity of the bioactive compounds of both the leaf and the flower and prepare a lyophilized product of them, from which medical ointments were formulated, since the topical application of has also not been studied. In vitro drug release, texture analysis and biocompatibility experiments were carried out, as well as the investigation of microbiological, antioxidant and anti-inflammatory properties. According to our results the composition and the selected excipients of the ointments have a great impact on the drug release, texture and bioavailability of the preparation. During the microbiological testing, the leaf was effective against and , but it did not significantly decrease IL-4 production when it was tested on HaCaT cells. is a promising herb, and its topical application in antimicrobial therapy can be a useful addition to modern medical therapy.