The Molecular Interactions of ZIKV and DENV with the Type-I IFN Response

Zika Virus (ZIKV) and Dengue Virus (DENV) are related viruses of the Flavivirus genus that cause significant disease in humans. Existing control measures have been ineffective at curbing the increasing global incidence of infection for both viruses and they are therefore prime targets for new vaccin...

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Bibliographic Details
Published in:Vaccines (Basel) 2020-09, Vol.8 (3), p.530
Main Authors: Coldbeck-Shackley, Rosa C., Eyre, Nicholas S., Beard, Michael R.
Format: Article
Language:English
Subjects:
DENV
evasion
IFN
innate immunity
interferon
Review
ZIKV
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Summary:Zika Virus (ZIKV) and Dengue Virus (DENV) are related viruses of the Flavivirus genus that cause significant disease in humans. Existing control measures have been ineffective at curbing the increasing global incidence of infection for both viruses and they are therefore prime targets for new vaccination strategies. Type-I interferon (IFN) responses are important in clearing viral infection and for generating efficient adaptive immune responses towards infection and vaccination. However, ZIKV and DENV have evolved multiple molecular mechanisms to evade type-I IFN production. This review covers the molecular interactions, from detection to evasion, of these viruses with the type-I IFN response. Additionally, we discuss how this knowledge can be exploited to improve the design of new vaccine strategies.
ISSN:2076-393X
2076-393X
DOI:10.3390/vaccines8030530