Clinical Pathological Characteristics and Prognosis of Multigene Co-Mutations in Elderly Patients With Non-Small Cell Lung Cancer: A Retrospective Analysis

• Published in: Clinical Medicine Insights. Oncology 2023-01, Vol.17, p.11795549231211505-11795549231211505
• Main Authors: Li, Wanjing, Chang, Fangqun, Zhang, Hao, Meng, Furong, Ke, Zhangyan, Zhang, Yanbei
• Format: Article
• Language: English
• Subjects: Lung cancer; Medical prognosis; Mutation; Original
• ISSN: 1179-5549; 1179-5549
• DOI: 10.1177/11795549231211505

Background: With the development and wide application of next-generation sequencing (NGS), multiple-gene mutations related to lung cancer are detected using this technology. Notably, even multigene concomitant mutations (co-mutations), which occur at a relatively low incidence, can be detected more effectively using NGS. It is well-known that the percentages of non-small cell lung cancer (NSCLC) in the elderly lung cancer population are also gradually increasing, while its prognosis is hard and the quality of long-term survival is poor. This study aimed at investigating the common clinicopathologic features of multigene co-mutations for better evaluating the prognosis of elderly NSCLC patients. Methods: A total of 464 NSCLC patients were divided into 3 groups according to the types of gene mutation, whose clinical data were retrospectively analyzed. Results: In total, 38.36% (178/464) of NSCLC patients were in the nonmutation group, 50% in the single-gene mutation group, and 11.64% in the multigene co-mutation group. Nonmutation, single-gene mutation, and co-mutation groups were all prone to occur in male adenocarcinoma patients (P