Research Progress on the Mechanism of Sepsis Induced Myocardial Injury

Sepsis is an abnormal condition with multiple organ dysfunctions caused by the uncontrolled infection response and one of the major diseases that seriously hang over global human health. Besides, sepsis is characterized by high morbidity and mortality, especially in intensive care unit (ICU). Among...

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Bibliographic Details
Published in:Journal of inflammation research 2022-07, Vol.15, p.4275-4290
Main Authors: Bi, Cheng-Fei, Liu, Jia, Yang, Li-Shan, Zhang, Jun-Fei
Format: Article
Language:English
Subjects:
Apoptosis
Autophagy
Cardiomyocytes
China
Complications and side effects
Fatalities
Gene expression
Infection
Infections
Inflammation
mechanism
Medical prognosis
Mitochondria
Morbidity
Mortality
Oxidative stress
Pathophysiology
Phosphatase
Phosphorylation
Proteins
Pyroptosis
Review
Sepsis
sepsis induced myocardial injury
signaling pathway
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Summary:Sepsis is an abnormal condition with multiple organ dysfunctions caused by the uncontrolled infection response and one of the major diseases that seriously hang over global human health. Besides, sepsis is characterized by high morbidity and mortality, especially in intensive care unit (ICU). Among the numerous subsequent organ injuries of sepsis, myocardial injury is one of the most common complications and the main cause of death in septic patients. To better manage septic inpatients, it is necessary to understand the specific mechanisms of sepsis induced myocardial injury (SIMI). Therefore, this review will elucidate the pathophysiology of SIMI from the following certain mechanisms: apoptosis, mitochondrial damage, autophagy, excessive inflammatory response, oxidative stress and pyroptosis, and outline current therapeutic strategies and potential approaches in SIMI. Keywords: sepsis induced myocardial injury, mechanism, signaling pathway
ISSN:1178-7031
1178-7031
DOI:10.2147/JIR.S374117