10351 Antibiotic Use for Respiratory Syncytial Virus in the Middle East: A Surveillance Study in Hospitalized Jordanian Children

ABSTRACT IMPACT: Antibiotic stewardship guidelines should consider the barriers clinicians in low- and middle-income countries face due to limited biomarkers for determining the etiologic pathogen for viral infections like respiratory syncytial virus (RSV) that have a similar presentation to bacteri...

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Bibliographic Details
Published in:Journal of clinical and translational science 2021-03, Vol.5 (s1), p.28-28
Main Authors: Rankin, Danielle A., Khankari, Nikhil K., Haddadin, Zaid, Hamdan, Olla, Faouri, Samir, Shehabi, Asem, Williams, John V., Khuri-Bulos, Najwa, Halasa, Natasha B.
Format: Article
Language:English
Subjects:
Clinical Epidemiology
Translational Science, Policy, & Health Outcomes Science
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Summary:ABSTRACT IMPACT: Antibiotic stewardship guidelines should consider the barriers clinicians in low- and middle-income countries face due to limited biomarkers for determining the etiologic pathogen for viral infections like respiratory syncytial virus (RSV) that have a similar presentation to bacterial infections. OBJECTIVES/GOALS: We aimed to evaluate antibiotic administration practices in children who were hospitalized at a government-run hospital in Amman, Jordan, where point-of-care testing is limited. We hypothesized those with RSV are more likely to be administered antibiotics during their hospitalization than children without RSV. METHODS/STUDY POPULATION: We conducted a cross-sectional cohort study in Jordanian children hospitalized with history of acute respiratory symptoms and/or fever from 2010 to 2013. Admitting diagnoses were dichotomized into suspected viral- (e.g., bronchiolitis) and bacterial-like infection (e.g., sepsis, pneumonia). Stratifying by sex, we performed a polytomous logistic regression adjusting for age, underlying medical condition, maternal education, and region of residence to estimate prevalence odds ratios (PORs) and 95% confidence intervals for macrolides, broad-, and narrow-spectrum antibiotics during hospitalization. Sensitivity and specificity of admission diagnoses and laboratory results were compared. RESULTS/ANTICIPATED RESULTS: Children with a suspected viral-like admission diagnosis, compared to those with suspected bacterial-like, were 89% less likely to be administered a narrow-spectrum antibiotic (POR: 0.11; p
ISSN:2059-8661
2059-8661
DOI:10.1017/cts.2021.476