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Genome‐wide association studies reveal shared genetic haplotypes of autoimmune rheumatic and endocrine diseases with psychiatric disorders
Background Several studies have shown that autoimmune diseases are associated with psychiatric diseases like depression and psychosis. Genetic evidence supports this association. The aim of this study was to investigate if genetic variants predisposing to autoimmune diseases and psychiatric disorder...
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| Published in: | Brain and behavior 2023-04, Vol.13 (4), p.e2955-n/a |
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| container_issue | 4 |
| container_start_page | e2955 |
| container_title | Brain and behavior |
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| creator | Voskarides, Konstantinos Giannopoulou, Nefeli Eid, Rasha Parperis, Konstantinos Chatzittofis, Andreas |
| description | Background
Several studies have shown that autoimmune diseases are associated with psychiatric diseases like depression and psychosis. Genetic evidence supports this association. The aim of this study was to investigate if genetic variants predisposing to autoimmune diseases and psychiatric disorders are genetically linked, constructing the common haplotypes.
Methods
All registered single nucleotide polymorphisms (SNPs) in the Genome‐wide association studies (“GWAS catalog”) having been associated with autoimmune rheumatic and endocrine diseases were investigated for being in linkage disequilibrium with any psychiatric disorders’ associated SNPs. Analysis was performed by the LDtrait and LDhap bioinformatics tools.
Results
Multiple chromosomal regions have been detected containing rheumatic/endocrine diseases’ predisposing SNPs and psychiatric disorders’ predisposing SNPs. The genetic haplotypes have been constructed for some of these genetic regions. Six of the autoimmune rheumatic and endocrine diseases examined here share a common haplotype with psychiatric diseases at the HLA locus 6p21‐22.
Conclusion
Our study shows that autoimmune diseases and psychiatric diseases are genetically linked. Genetic haplotypes have been constructed, showing in detail this genetic linkage. |
| doi_str_mv | 10.1002/brb3.2955 |
| format | article |
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Several studies have shown that autoimmune diseases are associated with psychiatric diseases like depression and psychosis. Genetic evidence supports this association. The aim of this study was to investigate if genetic variants predisposing to autoimmune diseases and psychiatric disorders are genetically linked, constructing the common haplotypes.
Methods
All registered single nucleotide polymorphisms (SNPs) in the Genome‐wide association studies (“GWAS catalog”) having been associated with autoimmune rheumatic and endocrine diseases were investigated for being in linkage disequilibrium with any psychiatric disorders’ associated SNPs. Analysis was performed by the LDtrait and LDhap bioinformatics tools.
Results
Multiple chromosomal regions have been detected containing rheumatic/endocrine diseases’ predisposing SNPs and psychiatric disorders’ predisposing SNPs. The genetic haplotypes have been constructed for some of these genetic regions. Six of the autoimmune rheumatic and endocrine diseases examined here share a common haplotype with psychiatric diseases at the HLA locus 6p21‐22.
Conclusion
Our study shows that autoimmune diseases and psychiatric diseases are genetically linked. Genetic haplotypes have been constructed, showing in detail this genetic linkage.</description><identifier>ISSN: 2162-3279</identifier><identifier>EISSN: 2162-3279</identifier><identifier>DOI: 10.1002/brb3.2955</identifier><identifier>PMID: 36924079</identifier><language>eng</language><publisher>United States: John Wiley & Sons, Inc</publisher><subject>Anorexia ; Anxiety ; Autism ; Autoimmune diseases ; Autoimmune Diseases - genetics ; Bipolar disorder ; Brief Report ; Brief Reports ; Comorbidity ; depression ; Diabetes ; Endocrine disorders ; Endocrine System Diseases ; Genes ; genetic linkage ; Genetic Predisposition to Disease - genetics ; Genome-Wide Association Study ; Graves disease ; Haplotypes ; HLA ; Humans ; Linkage Disequilibrium ; Mental disorders ; Mental Disorders - genetics ; Peer review ; Polymorphism, Single Nucleotide ; Psoriasis ; Psychosis ; Rheumatoid arthritis ; Schizophrenia ; Scleroderma</subject><ispartof>Brain and behavior, 2023-04, Vol.13 (4), p.e2955-n/a</ispartof><rights>2023 The Authors. published by Wiley Periodicals LLC.</rights><rights>2023 The Authors. Brain and Behavior published by Wiley Periodicals LLC.</rights><rights>2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5485-9cc234e0686cbb7c9a759c096435d8b83ca88daa59a627605d3fadac10200b8a3</citedby><cites>FETCH-LOGICAL-c5485-9cc234e0686cbb7c9a759c096435d8b83ca88daa59a627605d3fadac10200b8a3</cites><orcidid>0000-0002-6635-9564 ; 0000-0002-3705-3451</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2799741888/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2799741888?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,11562,25753,27924,27925,37012,37013,44590,46052,46476,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36924079$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-206372$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Voskarides, Konstantinos</creatorcontrib><creatorcontrib>Giannopoulou, Nefeli</creatorcontrib><creatorcontrib>Eid, Rasha</creatorcontrib><creatorcontrib>Parperis, Konstantinos</creatorcontrib><creatorcontrib>Chatzittofis, Andreas</creatorcontrib><title>Genome‐wide association studies reveal shared genetic haplotypes of autoimmune rheumatic and endocrine diseases with psychiatric disorders</title><title>Brain and behavior</title><addtitle>Brain Behav</addtitle><description>Background
Several studies have shown that autoimmune diseases are associated with psychiatric diseases like depression and psychosis. Genetic evidence supports this association. The aim of this study was to investigate if genetic variants predisposing to autoimmune diseases and psychiatric disorders are genetically linked, constructing the common haplotypes.
Methods
All registered single nucleotide polymorphisms (SNPs) in the Genome‐wide association studies (“GWAS catalog”) having been associated with autoimmune rheumatic and endocrine diseases were investigated for being in linkage disequilibrium with any psychiatric disorders’ associated SNPs. Analysis was performed by the LDtrait and LDhap bioinformatics tools.
Results
Multiple chromosomal regions have been detected containing rheumatic/endocrine diseases’ predisposing SNPs and psychiatric disorders’ predisposing SNPs. The genetic haplotypes have been constructed for some of these genetic regions. Six of the autoimmune rheumatic and endocrine diseases examined here share a common haplotype with psychiatric diseases at the HLA locus 6p21‐22.
Conclusion
Our study shows that autoimmune diseases and psychiatric diseases are genetically linked. Genetic haplotypes have been constructed, showing in detail this genetic linkage.</description><subject>Anorexia</subject><subject>Anxiety</subject><subject>Autism</subject><subject>Autoimmune diseases</subject><subject>Autoimmune Diseases - genetics</subject><subject>Bipolar disorder</subject><subject>Brief Report</subject><subject>Brief Reports</subject><subject>Comorbidity</subject><subject>depression</subject><subject>Diabetes</subject><subject>Endocrine disorders</subject><subject>Endocrine System Diseases</subject><subject>Genes</subject><subject>genetic linkage</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Genome-Wide Association Study</subject><subject>Graves disease</subject><subject>Haplotypes</subject><subject>HLA</subject><subject>Humans</subject><subject>Linkage Disequilibrium</subject><subject>Mental disorders</subject><subject>Mental Disorders - genetics</subject><subject>Peer review</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Psoriasis</subject><subject>Psychosis</subject><subject>Rheumatoid arthritis</subject><subject>Schizophrenia</subject><subject>Scleroderma</subject><issn>2162-3279</issn><issn>2162-3279</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNp1ksFu1DAQQCMEolXbAz-AInGhh20dO3bsE2oLtJUqISHgak3sycarJF7spKu98QEc-Ea-BO9uqbpI-GJr_PxmbE-WvSrIWUEIPa9Dzc6o4vxZdkgLQWeMVur5k_VBdhLjgqTBi5KW5GV2wIRKi0odZj-vcfA9_v7xa-Us5hCjNw5G54c8jpN1GPOA9whdHlsIaPM5Djg6k7ew7Py4XibANzlMo3d9Pw2YhxanHjYIDDbHwXoTXIpbFxFiwldubPNlXJs2JQqJSzs-WAzxOHvRQBfx5GE-yr5-_PDl6mZ29-n69uribmZ4KflMGUNZiURIYeq6MgoqrgxRomTcyloyA1JaAK5A0EoQblkDFkxBKCG1BHaU3e681sNCL4PrIay1B6e3AR_mGkK6QYe6ASkqRsEgq0prSilVYWsCltIGgPDkmu1ccYXLqd6zvXffLra2qZ80JYJVNPHvdnyCe7QGhzFAt3dsf2dwrZ77e50-W1WkKpLh7YMh-O8TxlH3LhrsOhjQT1FTSYiggguZ0Df_oAs_hSG9rU6NoaqykHJDne4oE3yMAZvHagqySUv1psf0pscS-_pp-Y_k345KwPkOWLkO1_836cvPl2yr_AOTH-Au</recordid><startdate>202304</startdate><enddate>202304</enddate><creator>Voskarides, Konstantinos</creator><creator>Giannopoulou, Nefeli</creator><creator>Eid, Rasha</creator><creator>Parperis, Konstantinos</creator><creator>Chatzittofis, Andreas</creator><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><general>Wiley</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><scope>ADHXS</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>D93</scope><scope>ZZAVC</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-6635-9564</orcidid><orcidid>https://orcid.org/0000-0002-3705-3451</orcidid></search><sort><creationdate>202304</creationdate><title>Genome‐wide association studies reveal shared genetic haplotypes of autoimmune rheumatic and endocrine diseases with psychiatric disorders</title><author>Voskarides, Konstantinos ; Giannopoulou, Nefeli ; Eid, Rasha ; Parperis, Konstantinos ; Chatzittofis, Andreas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5485-9cc234e0686cbb7c9a759c096435d8b83ca88daa59a627605d3fadac10200b8a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Anorexia</topic><topic>Anxiety</topic><topic>Autism</topic><topic>Autoimmune diseases</topic><topic>Autoimmune Diseases - genetics</topic><topic>Bipolar disorder</topic><topic>Brief Report</topic><topic>Brief Reports</topic><topic>Comorbidity</topic><topic>depression</topic><topic>Diabetes</topic><topic>Endocrine disorders</topic><topic>Endocrine System Diseases</topic><topic>Genes</topic><topic>genetic linkage</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>Genome-Wide Association Study</topic><topic>Graves disease</topic><topic>Haplotypes</topic><topic>HLA</topic><topic>Humans</topic><topic>Linkage Disequilibrium</topic><topic>Mental disorders</topic><topic>Mental Disorders - genetics</topic><topic>Peer review</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Psoriasis</topic><topic>Psychosis</topic><topic>Rheumatoid arthritis</topic><topic>Schizophrenia</topic><topic>Scleroderma</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Voskarides, Konstantinos</creatorcontrib><creatorcontrib>Giannopoulou, Nefeli</creatorcontrib><creatorcontrib>Eid, Rasha</creatorcontrib><creatorcontrib>Parperis, Konstantinos</creatorcontrib><creatorcontrib>Chatzittofis, Andreas</creatorcontrib><collection>Wiley-Blackwell Open Access Collection</collection><collection>Wiley Free Archive</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Psychology Database (ProQuest)</collection><collection>ProQuest Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest - Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SWEPUB Umeå universitet full text</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SWEPUB Umeå universitet</collection><collection>SwePub Articles full text</collection><collection>Open Access: DOAJ - Directory of Open Access Journals</collection><jtitle>Brain and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Voskarides, Konstantinos</au><au>Giannopoulou, Nefeli</au><au>Eid, Rasha</au><au>Parperis, Konstantinos</au><au>Chatzittofis, Andreas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genome‐wide association studies reveal shared genetic haplotypes of autoimmune rheumatic and endocrine diseases with psychiatric disorders</atitle><jtitle>Brain and behavior</jtitle><addtitle>Brain Behav</addtitle><date>2023-04</date><risdate>2023</risdate><volume>13</volume><issue>4</issue><spage>e2955</spage><epage>n/a</epage><pages>e2955-n/a</pages><issn>2162-3279</issn><eissn>2162-3279</eissn><abstract>Background
Several studies have shown that autoimmune diseases are associated with psychiatric diseases like depression and psychosis. Genetic evidence supports this association. The aim of this study was to investigate if genetic variants predisposing to autoimmune diseases and psychiatric disorders are genetically linked, constructing the common haplotypes.
Methods
All registered single nucleotide polymorphisms (SNPs) in the Genome‐wide association studies (“GWAS catalog”) having been associated with autoimmune rheumatic and endocrine diseases were investigated for being in linkage disequilibrium with any psychiatric disorders’ associated SNPs. Analysis was performed by the LDtrait and LDhap bioinformatics tools.
Results
Multiple chromosomal regions have been detected containing rheumatic/endocrine diseases’ predisposing SNPs and psychiatric disorders’ predisposing SNPs. The genetic haplotypes have been constructed for some of these genetic regions. Six of the autoimmune rheumatic and endocrine diseases examined here share a common haplotype with psychiatric diseases at the HLA locus 6p21‐22.
Conclusion
Our study shows that autoimmune diseases and psychiatric diseases are genetically linked. Genetic haplotypes have been constructed, showing in detail this genetic linkage.</abstract><cop>United States</cop><pub>John Wiley & Sons, Inc</pub><pmid>36924079</pmid><doi>10.1002/brb3.2955</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0002-6635-9564</orcidid><orcidid>https://orcid.org/0000-0002-3705-3451</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Wiley-Blackwell Open Access Collection; Open Access: PubMed Central; ProQuest - Publicly Available Content Database |
| subjects | Anorexia Anxiety Autism Autoimmune diseases Autoimmune Diseases - genetics Bipolar disorder Brief Report Brief Reports Comorbidity depression Diabetes Endocrine disorders Endocrine System Diseases Genes genetic linkage Genetic Predisposition to Disease - genetics Genome-Wide Association Study Graves disease Haplotypes HLA Humans Linkage Disequilibrium Mental disorders Mental Disorders - genetics Peer review Polymorphism, Single Nucleotide Psoriasis Psychosis Rheumatoid arthritis Schizophrenia Scleroderma |
| title | Genome‐wide association studies reveal shared genetic haplotypes of autoimmune rheumatic and endocrine diseases with psychiatric disorders |
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