Clinical significance of endometrial abnormalities: an observational study on 1020 women undergoing hysteroscopic surgery

• Published in: BMC women's health 2022-04, Vol.22 (1), p.106-106, Article 106
• Main Authors: Patrizi, Lodovico, Ticconi, Carlo, Borelli, Barbara, Finocchiaro, Susanna, Chiaramonte, Carlo, Sesti, Francesco, Mauriello, Alessandro, Exacoustos, Caterina, Casadei, Luisa
• Format: Article
• Language: English
• Subjects: Asymptomatic; AUB; Breast cancer; Care and treatment; Clinical significance; Complications and side effects; Diabetes; Endometrial atypia and cancer; Endometrial cancer; Endometrial Neoplasms - pathology; Endometrial Neoplasms - surgery; Endometrial polyps; Endometrium; Endometrium - diagnostic imaging; Endometrium - pathology; Female; Hospitals; Humans; Hypertension; Hypotheses; Hysteroscopy; Hysteroscopy - methods; Lesions; Menopause; Methods; Observational studies; Patients; Polyps; Polyps - diagnostic imaging; Polyps - surgery; Postmenopausal women; Precancerous Conditions; Pregnancy; Retrospective Studies; Risk factors; Software; Statistical analysis; Statistics; Surgery; Transvaginal ultrasonography; Ultrasonic imaging; Ultrasonography; Uterine bleeding; Uterine Diseases - diagnostic imaging; Uterine Diseases - surgery; Uterine Hemorrhage - etiology; Uterine Neoplasms - pathology; Vagina; Womens health
• ISSN: 1472-6874; 1472-6874
• DOI: 10.1186/s12905-022-01682-5

The overall clinical significance of the finding of endometrial abnormalities in predicting premalignant/malignant endometrial lesions is still incompletely determined. For this reason the management, surgical or expectant, of women in which an endometrial abnormality has been detected is debated. This retrospective study was carried out on 1020 consecutive women, 403 premenopausal and 617 postmenopausal, who underwent operative hysteroscopy in a University Hospital for suspected endometrial abnormalities, which were detected by transvaginal ultrasound (TVS) and/or office hysteroscopy. In these women, the clinical characteristics and findings at TVS and hysteroscopy were evaluated in relation to the presence/absence of premalignant/malignant endometrial lesions at pathology report. The clinical characteristics considered were significantly different when the study women were compared according to their menopausal status. Premalignant/malignant lesions were found in 34/1020 (3.33%) women. Complex hyperplasia with atypia and endometrial cancer were detected in 22 (2.15%) and 12 (1.17%) cases, respectively. The postmenopausal women had a significantly higher risk of premalignant/malignant lesions than premenopausal women (O.R. = 5.098 [95% C.I.: 1.782-14.582], P