Application of Ginsenoside Rd in Periodontitis With Inhibitory Effects on Pathogenicity, Inflammation, and Bone Resorption

• Published in: Frontiers in cellular and infection microbiology 2022-04, Vol.12, p.813953-813953
• Main Authors: Zhou, Shuhui, Ji, Yaoting, Yao, Hantao, Guo, Haiying, Zhang, Zichen, Wang, Zijun, Du, Minquan
• Format: Article
• Language: English
• Subjects: Alveolar Bone Loss - drug therapy; Alveolar Bone Loss - microbiology; Alveolar Bone Loss - prevention & control; Animals; Anti-Bacterial Agents; Cellular and Infection Microbiology; Disease Models, Animal; ginsenoside; Ginsenosides; inflammation; Inflammation - drug therapy; Mice; osteoclastogenesis; periodontitis; Periodontitis - drug therapy; Periodontitis - microbiology; Porphyromonas gingivalis; Virulence
• ISSN: 2235-2988; 2235-2988
• DOI: 10.3389/fcimb.2022.813953

Periodontitis is a worldwide oral disease induced by the interaction of subgingival bacteria and host response and is characterized by local inflammation, bone resorption, and tooth loss. Ginsenoside Rd (Rd) is a biologically active component derived from Panax ginseng and has been demonstrated to exert antibacterial and anti-inflammatory activities. This study aims to investigate the inhibitory efficiency of Rd towards ( ), periodontal inflammatory response, and osteoclastogenesis and to further validate the results in a mouse periodontitis model, thus, evaluate the potential effects of Rd on the control and prevention of periodontitis. According to the results, Rd exerted excellent antibacterial activities against planktonic , along with attenuating virulence and inhibiting its biofilms. Meanwhile, the inflammatory cytokine production and osteoclastogenesis were remarkably inhibited by Rd both and . Furthermore, Rd efficiently ameliorated the subgingival abundance and suppressed the alveolar bone resorption as well. In conclusion, Rd has the potential to be developed as a promising medication in the control and prevention of periodontitis.