Acute Polyserositis with Cardiac Tamponade and Bilateral Refractory Pleural Effusion after ChAdOx1 nCoV-19 Vaccination

The association of SARS-CoV-2 messenger ribonucleic acid vaccines with pericarditis in young adults has been reported. However, data regarding other types of vaccines are extremely limited. We presented a 94-year-old man with rapidly progressive dyspnea and fatigue six days after his first ChAdOx1 n...

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Bibliographic Details
Published in:Vaccines (Basel) 2022-08, Vol.10 (8), p.1286
Main Authors: Li, Guan-Yi, Lee, Chang-Ching, Huang, Chin-Chou
Format: Article
Language:English
Subjects:
Autoimmune diseases
Biopsy
Blood pressure
cardiac tamponade
Cardiovascular disease
Case Report
Catheters
ChAdOx1 nCoV-19
Colchicine
Coronaviruses
COVID-19
COVID-19 vaccines
Diagnosis
Dyspnea
Granulomas
Heart
Heart failure
Hospitalization
Infections
Inflammation
Lupus
Myocarditis
Pandemics
Peptides
Pericarditis
Pleural effusion
Pleural effusions
Pleurisy
Polymerase chain reaction
Polyserositis
Prednisolone
Respiration
Ribonucleic acid
Risk factors
RNA
Severe acute respiratory syndrome coronavirus 2
Tamponade
Thyroid gland
Tuberculosis
vaccine
Vaccines
Vectors (Biology)
Young adults
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Summary:The association of SARS-CoV-2 messenger ribonucleic acid vaccines with pericarditis in young adults has been reported. However, data regarding other types of vaccines are extremely limited. We presented a 94-year-old man with rapidly progressive dyspnea and fatigue six days after his first ChAdOx1 nCoV-19 vaccination. Impending cardiac tamponade and bilateral pleural effusion were found. Hence, massive yellowish pericardial and pleural effusion were drained. However, the pleural effusion persisted and pigtail catheters were inserted bilaterally. After serial studies including surgical pleural biopsy, acute polyserositis (pericarditis and pleurisy) was diagnosed. Anti-inflammatory treatment with colchicine and prednisolone was administered. All effusions resolved accordingly. This rare case sheds light on the presentation of ChAdOx1 nCoV-19 vaccine-related acute polyserositis. In conclusion, awareness of this potential adverse event may facilitate the diagnosis for unexplained pericardial or pleural effusion after vaccination.
ISSN:2076-393X
2076-393X
DOI:10.3390/vaccines10081286