The Interaction of HLA-C1/KIR2DL2/L3 Promoted KIR2DL2/L3 Single-Positive/NKG2C-Positive Natural Killer Cell Reconstitution, Raising the Incidence of aGVHD after Hematopoietic Stem Cell Transplantation

NKG2C+ natural killer (NK) cell plays a vital role in CMV infection control after hematopoietic stem cell transplantation (HSCT). However, the modulation on NKG2C+ NK cell reconstitution is still unclear. NK cell education is affected by the interactions of HLA-I/killer immunoglobulin receptor (KIR)...

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Published in:Frontiers in immunology 2022-04, Vol.13, p.814334-814334
Main Authors: Zuo, Wei, Yu, Xing-Xing, Liu, Xue-Fei, Chang, Ying-Jun, Wang, Yu, Zhang, Xiao-Hui, Xu, Lan-Ping, Liu, Kai-Yan, Zhao, Xiao-Su, Huang, Xiao-Jun, Zhao, Xiang-Yu
Format: Article
Language:English
Subjects:
HLA-C (C1/C2)
HSCT
Immunology
KIR2DL2
NK receptor
NK reconstitution
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Summary:NKG2C+ natural killer (NK) cell plays a vital role in CMV infection control after hematopoietic stem cell transplantation (HSCT). However, the modulation on NKG2C+ NK cell reconstitution is still unclear. NK cell education is affected by the interactions of HLA-I/killer immunoglobulin receptor (KIR). Our aim is to figure out which HLA-I/KIR interaction plays a dominant role in NKG2C+ NK education. Based on allogeneic haploidentical HSCT, we investigated the expansion and function of single KIR positive NKG2C+ NK cells the interaction of KIR with both donor HLA and recipient HLA at days 30, 90, and 180 after HSCT. KIR2DL2/L3 single-positive/NKG2C cells were significantly expanded compared with KIR2DL1 or KIR3DL1 single-positive/NKG2C cells when donors and recipients were both HLA-C1/C1 or HLA-C1C1BW4 ( < 0.05), with higher NKp30 expression ( < 0.05). Moreover, the proportion of single KIR positive NK cells increased in both NKG2C /NKG2A NK cells and conventional NKG2C /NKG2A NK cells over time. We also observed that increased proportion of KIR2DL2/L3 single-positive/NKG2C NK cells correlated with higher incidence of acute graft-versus-host disease (aGVHD). Our study allows a better understanding of HLA-I/KIR interaction in the NKG2C+ NK cell education after HSCT.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2022.814334