Monocyte/Lymphocyte Ratio and Cardiovascular Disease Mortality in Peritoneal Dialysis Patients

Objectives. The monocyte-to-lymphocyte ratio (MLR), as a new marker of the systemic inflammatory response, is associated with cardiovascular disease (CVD) mortality in the general population and hemodialysis patients. However, the association between the MLR and CVD mortality in peritoneal dialysis...

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Bibliographic Details
Published in:Mediators of inflammation 2020, Vol.2020 (2020), p.1-9
Main Authors: Feng, Xiaoran, Peng, Fen-Fen, Wang, Niansong, Zhan, Xiaojiang, Wen, Yueqiang, Wu, Xianfeng
Format: Article
Language:English
Subjects:
Adult
Age
Aged
Analysis
Atherosclerosis
Biomarkers
Cardiovascular disease
Cardiovascular diseases
Cardiovascular Diseases - metabolism
China
Comorbidity
Coronary vessels
Diabetes
Female
Hematology
Hemodialysis
Humans
Hypertension
Inflammation
Kaplan-Meier Estimate
Lymphocytes
Male
Medical research
Medicine, Experimental
Middle Aged
Monocytes
Monocytes - cytology
Monocytes - metabolism
Mortality
Multicenter Studies as Topic
Patient outcomes
Peritoneal Dialysis
Peritoneum
Population
Proportional Hazards Models
Retrospective Studies
Rheumatic diseases
Risk assessment
Risk Factors
Software
Studies
Survival analysis
Triglycerides
Tumor necrosis factor-TNF
Uric acid
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Summary:Objectives. The monocyte-to-lymphocyte ratio (MLR), as a new marker of the systemic inflammatory response, is associated with cardiovascular disease (CVD) mortality in the general population and hemodialysis patients. However, the association between the MLR and CVD mortality in peritoneal dialysis (PD) has received little attention. Methods. In this multicenter retrospective cohort study, 1753 incident PD patients from November 1, 2005, to June 30, 2017, with a baseline MLR were enrolled. The primary endpoint was CVD mortality. The association of MLR with CVD mortality was assessed using a multivariable-adjusted Cox model and the Fine and Gray competing risk model. Results. Of 1753 patients, the mean age was 51.1±14.9 years, 56.9% of patients were male, and the Charlson comorbidity index was 4.29±1.75. During the follow-up period of 31.2±18.4 months, 368 patients died, of which 200 (54.3%) deaths were caused by CVD events. CVD mortality rates for the lowest, middle, and highest MLR tertiles were 70.6, 78.4, and 88.9 per 1000 patient-years, respectively (P
ISSN:0962-9351
1466-1861
DOI:10.1155/2020/9852507