Action Sites and Clinical Application of HIF-1α Inhibitors

Hypoxia-inducible factor-1α (HIF-1α) is widely distributed in human cells, and it can form different signaling pathways with various upstream and downstream proteins, mediate hypoxia signals, regulate cells to produce a series of compensatory responses to hypoxia, and play an important role in the p...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2022-05, Vol.27 (11), p.3426
Main Authors: Xu, Renfeng, Wang, Fan, Yang, Hongqin, Wang, Zhengchao
Format: Article
Language:English
Subjects:
Amino acids
Cell cycle
Diabetes mellitus
disease treatment
Diseases
Gene expression
Growth factors
Health services
Heat shock proteins
HIF-1α
HIF-1α inhibitor
Hydrocarbons
Hypoxia
Hypoxia-inducible factor 1a
Inhibitors
Ischemia
Kinases
Leukemia
Mammals
Medical research
Physiology
Review
Signal transduction
Transcription factors
tumor
Tumors
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Summary:Hypoxia-inducible factor-1α (HIF-1α) is widely distributed in human cells, and it can form different signaling pathways with various upstream and downstream proteins, mediate hypoxia signals, regulate cells to produce a series of compensatory responses to hypoxia, and play an important role in the physiological and pathological processes of the body, so it is a focus of biomedical research. In recent years, various types of HIF-1α inhibitors have been designed and synthesized and are expected to become a new class of drugs for the treatment of diseases such as tumors, leukemia, diabetes, and ischemic diseases. This article mainly reviews the structure and functional regulation of HIF-1α, the modes of action of HIF-1α inhibitors, and the application of HIF-1α inhibitors during the treatment of diseases.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules27113426