Promise of G-Quadruplex Structure Binding Ligands as Epigenetic Modifiers with Anti-Cancer Effects

Evidences from more than three decades of work support the function of non-duplex DNA structures called G-quadruplex (G4) in important processes like transcription and replication. In addition, G4 structures have been studied in connection with DNA base modifications and chromatin/nucleosome arrange...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2019-02, Vol.24 (3), p.582
Main Authors: Sengupta, Antara, Ganguly, Akansha, Chowdhury, Shantanu
Format: Article
Language:English
Subjects:
Binding
Binding sites
Cancer
Chromatin
Cyclin-dependent kinases
Deoxyribonucleic acid
dietary G4 structure-binding molecules
DNA
DNA methylation
Epigenetics
G4-interacting proteins
Genes
Genomes
Histones
Kinases
Ligands
MicroRNAs
Molecular structure
Proteins
Regulatory sequences
replication
Review
Telomerase
Transcription
Transcription factors
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Summary:Evidences from more than three decades of work support the function of non-duplex DNA structures called G-quadruplex (G4) in important processes like transcription and replication. In addition, G4 structures have been studied in connection with DNA base modifications and chromatin/nucleosome arrangements. Recent work, interestingly, shows promise of G4 structures, through interaction with G4 structure-interacting proteins, in epigenetics-in both DNA and histone modification. Epigenetic changes are found to be intricately associated with initiation as well as progression of cancer. Multiple oncogenes have been reported to harbor the G4 structure at regulatory regions. In this context, G4 structure-binding ligands attain significance as molecules with potential to modify the epigenetic state of chromatin. Here, using examples from recent studies we discuss the emerging role of G4 structures in epigenetic modifications and, therefore, the promise of G4 structure-binding ligands in epigenetic therapy.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules24030582