Preoperative uric acid predicts in-hospital death in patients with acute type a aortic dissection

• Published in: Journal of cardiothoracic surgery 2020-01, Vol.15 (1), p.21-21, Article 21
• Main Authors: Zhang, Yiran, Xu, Xingjie, Lu, Yuan, Guo, Lei, Ma, Liang
• Format: Article
• Language: English
• Subjects: Acute Disease; Acute type A aortic dissection; Adult; Age; Aged; Aneurysm, Dissecting - blood; Aneurysm, Dissecting - mortality; Aneurysm, Dissecting - surgery; Aorta; Aorta - surgery; Aortic Aneurysm - blood; Aortic Aneurysm - surgery; Aortic dissection; Blood platelets; Blood pressure; Comparative analysis; Coronary vessels; Death; Dimers; Dissection; Family medical history; Female; Health aspects; Health risk assessment; Hospital Mortality; Hospitals; Humans; In-hospital mortality; Laboratories; Logistic Models; Male; Medical research; Medical schools; Middle Aged; Mortality; Patients; Predictive Value of Tests; Purines; Regression analysis; Retrospective Studies; Risk analysis; Risk Factors; ROC Curve; Studies; Subgroups; Surgery; Taiwan; Thorax; Time; Transplants & implants; Uric acid; Uric Acid - blood; Veins & arteries
• ISSN: 1749-8090; 1749-8090
• DOI: 10.1186/s13019-020-1066-9

The present study aimed to evaluate the value of admission serum uric acid (UA) level in predicting in-hospital risk of death in patients with acute type A aortic dissection (AAAD). From January 2016 to June 2019, 186 consecutive patients with AAAD who underwent thoracic aortic surgery were retrospectively studied. Serum UA levels were measured on admission. Forward conditional logistic regression was performed to identify independent risk factors for in-hospital death. Receiver operating characteristic (ROC) analysis was performed to assess the most clinical useful level of serum UA for predicting postoperative in-hospital mortality. Increased level of serum UA was found in non-survivors compared with those survived (446 ± 123 vs 371 ± 111 umol/L, p