Using Murine Models to Investigate Tumor-Lymphoid Interactions: Spotlight on Chronic Lymphocytic Leukemia and Angioimmunoblastic T-Cell Lymphoma

The role of the tumor microenvironment in leukemias and lymphomas is well established, yet the intricacies of how the malignant cells regulate and influence their non-malignant counterparts remain elusive. For example, chronic lymphocytic leukemia (CLL) is an expansion of malignant CD5 CD19 B cells,...

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Bibliographic Details
Published in:Frontiers in oncology 2017-05, Vol.7, p.86-86
Main Authors: Herek, Tyler A, Cutucache, Christine E
Format: Article
Language:English
Subjects:
angioimmunoblastic T-cell lymphoma
chronic lymphocytic leukemia
immune surveillance
lymphoma
Oncology
tumor-induced immunosuppression
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Summary:The role of the tumor microenvironment in leukemias and lymphomas is well established, yet the intricacies of how the malignant cells regulate and influence their non-malignant counterparts remain elusive. For example, chronic lymphocytic leukemia (CLL) is an expansion of malignant CD5 CD19 B cells, yet the non-malignant T cells play just as large of a role in disease presentation and etiology. Herein, we review the dynamic tumor cell to lymphoid repertoire interactions found in two non-Hodgkin's lymphoma subtypes: CLL and angioimmunoblastic T-cell lymphoma. We aim to highlight the pivot work done in the murine models which recapitulate these diseases and explore the insights that can be gained from studying the immuno-oncological regulation of non-malignant lymphoid counterparts.
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2017.00086