Fatal fulminant hepatitis in a patient taking abiraterone acetate: a case report

Abiraterone acetate is a steroidal inhibitor of cytochrome P450 17A1 indicated in the treatment of metastatic prostate cancer. This report examines the case of a 66-year-old patient diagnosed with prostate adenocarcinoma that had metastasized to the bones and lymph nodes. Treatment with abiraterone...

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Bibliographic Details
Published in:Frontiers in medicine 2023-06, Vol.10, p.1143244
Main Authors: Akpokavie, Dela, Gubert, Capucine, Abdelli, Imene, Stern, Alix O'Meara, Zender, Hervé
Format: Article
Language:English
Subjects:
abiraterone
case report
fulminant hepatitis
hepatotoxicity
Medicine
prostate cancer
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Summary:Abiraterone acetate is a steroidal inhibitor of cytochrome P450 17A1 indicated in the treatment of metastatic prostate cancer. This report examines the case of a 66-year-old patient diagnosed with prostate adenocarcinoma that had metastasized to the bones and lymph nodes. Treatment with abiraterone acetate and corticosteroid co-administration as well as LH-RH analog hormone therapy was initiated. Four and a half months later, the patient consulted for deterioration of general condition. Biologically, he developed a fulminant hepatitis of which he eventually died. An infectious or metabolic origin was ruled out. Oncological cause by either disease progression or second neoplastic process was eliminated by means of imaging. Hepatic toxicity was imputed to the treatment with abiraterone acetate. This case suggests that fulminant hepatitis on abiraterone acetate may be underestimated, and underscores the importance of regular monitoring of liver tests on this therapy.
ISSN:2296-858X
2296-858X
DOI:10.3389/fmed.2023.1143244